Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II.
产品描述 | Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. |
靶点活性 | RNA polymerase I:40.9±11.0 μM (Ki), RNA polymerase I:38.0±6.47 μM (Ki) |
体外活性 | Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. |
别名 | 6-Thio-ITP, Thio-ITP, 6-Mercaptopurine-riboside-5'-triphosphate, 6-Thioinosine 5′-triphosphate |
分子量 | 524.23 |
分子式 | C10H15N4O13P3S |
CAS No. | 27652-34-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Thio-ITP 27652-34-2 Thio ITP 6-Thio-ITP ThioITP 6-Mercaptopurine-riboside-5'-triphosphate 6-Thioinosine 5′-triphosphate Inhibitor inhibitor inhibit