Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 720 | 5日内发货 | ||
5 mg | ¥ 1,340 | 5日内发货 | ||
25 mg | ¥ 5,760 | 6-8周 | ||
50 mg | ¥ 7,490 | 6-8周 | ||
100 mg | ¥ 11,900 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,370 | 5日内发货 |
产品描述 | Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives. |
体外活性 | Benzylacyclouridine increases 5-FU-induced cytotoxicity in a number of human cancer cell lines[1]. Benzylacyclouridine (20-100 μM) reduces the rapid clearance of trace amounts of either [ 14 C]uridine or hyperphysiologic concentrations of non-labeled uridine by the isolated rat liver perfused with an artificial oxygen carrier[2]. |
体内活性 | Benzylacyclouridine (p.o. or i.v.) arrests the rapid degradation of a tracer dose of uridine into uracil in dogs and pigs[1]. Benzylacyclouridine exhibits the t 1/2 of 1.8-3.6 h in dogs, with bioavailability levels of 85% (30 mg/kg) and 42.5% (120 mg/kg)[1]. Benzylacyclouridine (120 mg/kg) exhibits the t 1/2 of 1.6-2.3 h, with a bioavailability of 40% in pigs[1]. |
别名 | 5-Benzylacyclouridine, BAU |
分子量 | 276.2878 |
分子式 | C14H16N2O4 |
CAS No. | 82857-69-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Benzylacyclouridine 82857-69-0 5-Benzylacyclouridine BAU Inhibitor inhibitor inhibit