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Betamethasone valerate

Name: Betamethasone valerate
Brand: TargetMol
SKU: T1163
Price: 139 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 倍他米松戊酸酯, Luxiq, Betnovate, Betamethasone 17-valerate, Betaderm

货号 T1163Cas号 2152-44-5 一键复制产品信息纯度: 99.32%

很棒

Betamethasone valerate (Luxiq) 的 17 戊酸酯，是一种具有抗炎活性的局部皮质类固醇。它能够抑制放射标记的糖皮质激素地塞米松与人表皮(IC50:5 nM)及小鼠皮肤(IC50:6 nM)的结合。它可用于研究复发性口疮。

Betamethasone valerate

一键复制产品信息

很棒

纯度: 99.32%

货号 T1163Cas号 2152-44-5

别名 倍他米松戊酸酯, Luxiq, Betnovate, Betamethasone 17-valerate, Betaderm

规格	价格	库存
10 mg	¥ 139	现货
25 mg	¥ 250	现货
50 mg	¥ 403	现货
100 mg	¥ 592	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.32%

颜色: 白色

资源下载: COA LCMS HNMR HPLC产品操作手册

产品介绍

Betamethasone valerate AI Summary

Betamethasone valerate exhibits a broad spectrum of bioactivities, prominently including anti-inflammatory and antiviral properties. In a murine chronic irritative contact dermatitis model, it significantly inhibited ear swelling (41.0%) and ear weight (38.0%) induced by TPA, and MPO activity (67.0%). It also demonstrated anti-inflammatory effects in a murine topical allergic contact dermatitis model, inhibiting TNFalpha by 75.0% at a dose of 0.003 mg. Its activity was comparable to betamethasone 17-valerate in the Tonelli croton oil ear tests with a topical potency of 1.0. Additionally, Betamethasone valerate showed a permeability coefficient in human skin of log Kp = -6.12, indicating low skin permeability. In antiviral studies, it inhibited SARS-CoV-2 induced cytotoxicity in Caco-2 cells (15.28% at 10 μM) and VERO-6 cells (0.09% at 10 μM) after 48 hours. It also showed a 2.908% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 μM. Moreover, it demonstrated potential efficacy against the SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of -0.1439. Betamethasone valerate showed relative bioactivity in various assays, including inhibition of Plasmodium falciparum proliferation, liver enzyme composite activity, and sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells. It also exhibited in vivo inverse agonist activity at RORgamma in a mouse model of imiquimod-induced skin inflammation with 72.0% attenuation of epidermal hyperplasia at a concentration of 0.01%. In human receptor binding assays, it showed a stronger inhibitory potential against human NR3C1 with an AC50 of 4.0 nM, despite generally having AC50 values greater than 10,000 nM for most other targets. Betamethasone valerate has a potency of 360.0 relative to fluocinolone 16,17-acetonide in the human vasoconstrictor test..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
别名	倍他米松戊酸酯, Luxiq, Betnovate, Betamethasone 17-valerate, Betaderm

化学信息

分子量	476.58
分子式	C₂₇H₃₇FO₆
CAS No.	2152-44-5
Smiles	C[C@@]12[C@@](OC(CCCC)=O)(C(CO)=O)[C@@H](C)C[C@]1([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
密度	1.24g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 58 mg/mL (121.7 mM), Sonication is recommended.

DMSO: 95 mg/mL (199.34 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0983 mL	10.4914 mL	20.9828 mL	104.9142 mL
5 mM	0.4197 mL	2.0983 mL	4.1966 mL	20.9828 mL
10 mM	0.2098 mL	1.0491 mL	2.0983 mL	10.4914 mL
20 mM	0.1049 mL	0.5246 mL	1.0491 mL	5.2457 mL
50 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0983 mL
100 mM	0.0210 mL	0.1049 mL	0.2098 mL	1.0491 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

use topical stomatitis recurrent Inhibitor inhibit GlucocorticoidReceptor Glucocorticoid Receptor glucocorticoid Betamethasone Valerate Betamethasone aphthous antiinflammatory

Betamethasone valerate

Betamethasone valerate