购物车
您的购物车当前为空
Riluzole
一键复制产品信息
很棒纯度: 99.88%
货号 T0349Cas号 1744-22-5
别名 利鲁唑, RP-54274, PK 26124
Riluzole (RP-54274) 是一种谷氨酸拮抗剂，用作抗惊厥药并延长肌萎缩侧索硬化症患者的生存期。它还抑制 GABA 摄取，IC50值为 43 μM。
其他形式的 “Riluzole”:
Riluzole
一键复制产品信息 很棒纯度: 99.88%
货号 T0349 别名 利鲁唑, RP-54274, PK 26124Cas号 1744-22-5
Riluzole (RP-54274) 是一种谷氨酸拮抗剂，用作抗惊厥药并延长肌萎缩侧索硬化症患者的生存期。它还抑制 GABA 摄取，IC50值为 43 μM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 165 | 现货 | |
| 10 mg | ¥ 223 | 现货 | |
| 25 mg | ¥ 346 | 现货 | |
| 50 mg | ¥ 493 | 现货 | |
| 100 mg | ¥ 797 | 现货 | |
| 500 mg | ¥ 2,380 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 257 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
Riluzole AI Summary
Riluzole exhibits a diverse range of bioactivities, indicating potential therapeutic applications across multiple domains. It functions as a sodium channel blocker with an IC50 of 4730 nM and a voltage-gated Ca2+ channel blocker in rat brain synaptosomes with an IC50 of 0.0 nM, showing potent inhibition of K+-evoked and veratridine-induced glutamate release. Additionally, Riluzole protects against seizures and has neuroprotective activity, demonstrated by efficacy in rat models of glutamate-induced convulsions (ED50 of 3.2 mg/kg) and focal stroke (effective at 4.0 mg/kg and 30.0 mg/kg).
The compound shows considerable metabolic stability, liver enzyme modulation, and potential for therapeutic applications in neuroprotection and stroke. It has a partition coefficient (logD7.4) of 3.43, high plasma protein binding of 97.13%, and demonstrates moderate lipophilicity (LogP 3.2). Additionally, it interferes with various cellular processes, including mitochondrial function, NFkB signaling, and Lamin A splicing, and inhibits several enzymes like BSEP (IC50 139000 nM) and human UGT1A1.
In terms of antibacterial and antifungal activity, Riluzole shows efficacy against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and several Candida species. It also demonstrates antivirals by inhibiting SARS-CoV-2 3CL-Pro protease and virus-induced cytotoxicity in VERO-6 cells.
Moreover, Riluzole has cytotoxic effects in some cell lines but displays neuroprotective properties against excitotoxic and oxidative stress in neuronal cells. Its high aqueous solubility, moderate passive permeability, and good liver microsomal stability underscore its potential as a drug candidate.
Overall, Riluzole’s broad bioactivity profile underscores its potential for therapeutic development in treating neurological disorders, infectious diseases, and metabolic conditions..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. |
| 靶点活性 | GABA:43 μM |
| 体外活性 | Tiluzole保护培养的神经元免受缺氧损伤,减少肌萎缩性侧索硬化患者CSF中毒性因子的损伤。Riluzole在非洲爪蟾卵母细胞中表达的离体兴奋性氨基酸受体的电生理学试验中抑制N-甲基-D-天冬氨酸(IC50 = 18 μM)和红藻氨酸(IC50 = 167 μM)诱发的电流。Riluzole能够稳定蛙坐骨神经和大鼠小脑颗粒细胞中激活的钠离子通道。Riluzole抑制谷氨基酸从培养的神经元和脑片释放。Riluzole通过非竞争性N-甲基-D-天冬氨酸受体也会阻断一些谷氨酸的突触后作用。 |
| 体内活性 | Riluzole能够轻易穿过血脑屏障.用8 mg/kg i.p. Riluzole治疗短暂性脑缺血的啮齿动物,可以完全抑制局部缺血诱发的谷氨基酸大量释放. |
| 别名 | 利鲁唑, RP-54274, PK 26124 |
| 分子量 | 234.2 |
| 分子式 | C8H5F3N2OS |
| CAS No. | 1744-22-5 |
| Smiles | NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2 |
| 密度 | 1.572 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 240 mg/mL (1024.77 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 43 mg/mL (183.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.35 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
| ||||||||||||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy Riluzole | purchase Riluzole | Riluzole cost | order Riluzole | Riluzole chemical structure | Riluzole in vivo | Riluzole in vitro | Riluzole formula | Riluzole molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441