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Risedronic Acid

Name: Risedronic Acid
Brand: TargetMol
SKU: T0379
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 利塞膦酸, Risedronate

货号 T0379Cas号 105462-24-6 一键复制产品信息纯度: 99.87%

很棒

Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。

Risedronic Acid

一键复制产品信息

很棒

纯度: 99.87%

货号 T0379Cas号 105462-24-6

别名 利塞膦酸, Risedronate

Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。

规格	价格	库存
5 mg	¥ 118	现货
10 mg	¥ 158	现货
25 mg	¥ 242	现货
50 mg	¥ 343	现货
100 mg	¥ 496	现货
500 mg	¥ 1,230	现货
1 g	¥ 1,830	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.87%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Risedronic Acid AI Summary

Risedronic Acid shows a diverse range of bioactivities, particularly in inhibiting various enzymes and parasites. It inhibits the growth of Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Toxoplasma gondii, Leishmania major, and Plasmodium species, with IC50 values varying from nanomolar to micromolar levels. The compound also demonstrates significant inhibitory activity against farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS) from multiple organisms, with IC50 values as low as 3.9 nM for human FPPS. Risedronic Acid shows considerable antiproliferative effects against various human and parasite cell lines. It has a notable therapeutic index, although toxicity concerns are present, particularly in its cytotoxicity against human KB and HepG2 cell lines. Additionally, it displays anti-inflammatory and bone resorption inhibition properties in rat models. Structurally, Risedronic Acid demonstrates high binding affinity to FPPS, significantly inhibiting enzyme activity and protein prenylation, indicating potential applications in treating diseases related to these pathways. Despite its broad spectrum of activity, it does not show significant inhibitory potential against Aquifex aeolicus IspH or recombinant GGTase 2 enzyme. Furthermore, it has displayed minimal antiviral activity against SARS-CoV-2 and weak binding affinity towards several human receptors..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
别名	利塞膦酸, Risedronate

化学信息

分子量	283.11
分子式	C₇H₁₁NO₇P₂
CAS No.	105462-24-6
Smiles	O.OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
密度	1.870 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: Insoluble

0.1 M NaOH: 16.25 mg/mL (57.4 mM), Sonication is recommended.

DMSO: 2.84 mg/mL (10.03 mM), Sonication is recommended.

溶液配制表

DMSO/0.1 M NaOH

	1mg	5mg	10mg	50mg
1 mM	3.5322 mL	17.6610 mL	35.3220 mL	176.6098 mL
5 mM	0.7064 mL	3.5322 mL	7.0644 mL	35.3220 mL
10 mM	0.3532 mL	1.7661 mL	3.5322 mL	17.6610 mL

0.1 M NaOH

	1mg	5mg	10mg	50mg
20 mM	0.1766 mL	0.8830 mL	1.7661 mL	8.8305 mL
50 mM	0.0706 mL	0.3532 mL	0.7064 mL	3.5322 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Risedronic Acid Inhibitor inhibit Hydroxylapatite Farnesyl pyrophosphate synthase

Risedronic Acid

Risedronic Acid

Risedronic Acid 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

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