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NF-1819

Name: NF-1819
Brand: TargetMol
SKU: T28165
Price: 2980 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.55%

货号 T28165Cas号 1881244-28-5

别名 NF1819, NF 1819

NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状，在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。

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NF-1819

一键复制产品信息

很棒

纯度: 99.55%

货号 T28165 别名 NF1819, NF 1819Cas号 1881244-28-5

规格	价格	库存
1 mg	¥ 237	现货
5 mg	¥ 561	现货
10 mg	¥ 990	现货
25 mg	¥ 1,980	现货
50 mg	¥ 2,980	现货
100 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 561	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.55%

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COA HNMR LCMS 产品操作手册

产品介绍

NF-1819 AI Summary

NF-1819 exhibits bioactivities primarily through selective inhibition of human FAAH over MAGL, with IC50 ratios ranging from 389.0 to 880.0. It demonstrates potent inhibition of rat MAGL, with an IC50 of 0.25 nM, and in various assays, it shows IC50 values between 4.6 to 10.0 nM for MAGL. Regarding cardiotoxicity, NF-1819 affects coronary perfusion pressure, heart rate, atrioventricular and intraventricular conduction times, and action potential duration in Sprague-Dawley rat hearts in a dose-dependent manner. In CD-1 mice, it alters 2-AG levels in the spinal cord and paw skin, and exhibits in vivo inhibition of MAGL, impacting 2-AG levels in response to formalin coadministration. The compound also displays antinociceptive properties, reducing formalin-induced pain response at a dosage of 0.3 mg/kg..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
别名	NF1819, NF 1819

化学信息

分子量	463.46
分子式	C₂₄H₂₂FN₅O₄
CAS No.	1881244-28-5
Smiles	[H][C@@]1(N(C2CCN(CC2)C(=O)n2cncn2)C(=O)[C@]1([H])c1ccc(F)cc1)c1ccc2OCOc2c1
密度	1.54 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (118.67 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1577 mL	10.7884 mL	21.5768 mL	107.8842 mL
5 mM	0.4315 mL	2.1577 mL	4.3154 mL	21.5768 mL
10 mM	0.2158 mL	1.0788 mL	2.1577 mL	10.7884 mL
20 mM	0.1079 mL	0.5394 mL	1.0788 mL	5.3942 mL
50 mM	0.0432 mL	0.2158 mL	0.4315 mL	2.1577 mL
100 mM	0.0216 mL	0.1079 mL	0.2158 mL	1.0788 mL