JAK3-IN-14

Name: JAK3-IN-14
Brand: TargetMol
SKU: T67754
Price: 1580 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.29%

货号 T67754Cas号 454234-24-3

JAK3-IN-14 是一种有效的、选择性的口服活性FLT3抑制剂，对FLT3-WT、FLT3-D835Y 和FLT3-D83H 的IC50分别为～40、8和4nM。

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JAK3-IN-14

一键复制产品信息

很棒

纯度: 98.29%

货号 T67754Cas号 454234-24-3

JAK3-IN-14 是一种有效的、选择性的口服活性FLT3抑制剂，对FLT3-WT、FLT3-D835Y 和FLT3-D83H 的IC50分别为～40、8和4nM。

规格	价格	库存
1 mg	¥ 1,580	现货
5 mg	¥ 4,570	现货
10 mg	¥ 6,660	现货
25 mg	¥ 9,880	现货
50 mg	¥ 13,300	现货
100 mg	¥ 17,900	现货
500 mg	¥ 35,800	现货
1 mL x 10 mM (in DMSO)	¥ 3,970	现货

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产品介绍

JAK3-IN-14 AI Summary

JAK3-IN-14 exhibits potent inhibitory activity against Janus Kinase 3 (JAK3) with an IC50 of 27.0-38.0 nM and shows selectivity over Janus Kinase 2 (JAK2) with an IC50 of 600.0 nM, yielding a selectivity ratio of 16.0. It also inhibits IL-2 induced proliferation of mouse CTLL cells with an IC50 of 760.0 nM and human T-cells with an IC50 of 250.0 nM. Additionally, it is effective against IL4-induced proliferation of TF1 cells with an IC50 of 600.0 nM and IL3-induced proliferation of TF1 cells with an IC50 of 500.0 nM. When administered intraperitoneally at a dose of 1 mg/kg, JAK3-IN-14 achieves a Cp max of 600.0 ng/mL, a Tmax of 0.5 hr, an AUC of 7686.0 ng·hr/mL, and a terminal T1/2 of 3.0 hr..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.
靶点活性	JAK2:600 nM, JAK3:38 nM

化学信息

分子量	287.32
分子式	C₁₈H₁₃N₃O
CAS No.	454234-24-3
Smiles	C(=C1C=2C(NC1=O)=CC=C(C2)C=3C=CC=NC3)C4=CC=CN4
密度	1.332 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (174.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4804 mL	17.4022 mL	34.8044 mL	174.0220 mL
5 mM	0.6961 mL	3.4804 mL	6.9609 mL	34.8044 mL
10 mM	0.3480 mL	1.7402 mL	3.4804 mL	17.4022 mL
20 mM	0.1740 mL	0.8701 mL	1.7402 mL	8.7011 mL
50 mM	0.0696 mL	0.3480 mL	0.6961 mL	3.4804 mL
100 mM	0.0348 mL	0.1740 mL	0.3480 mL	1.7402 mL