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Crotamiton

Name: Crotamiton
Brand: TargetMol
SKU: T0376
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.38%

货号 T0376Cas号 483-63-6

别名 克罗米通, Veteusan, Eurax, Crotamitone

Crotamiton (Eurax) 既是杀疥螨剂，可研究疥疮，也是止痒剂, 可除去疥疮寄生虫。

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Crotamiton

一键复制产品信息

很棒

纯度: 99.38%

货号 T0376 别名 克罗米通, Veteusan, Eurax, CrotamitoneCas号 483-63-6

Crotamiton (Eurax) 既是杀疥螨剂，可研究疥疮，也是止痒剂, 可除去疥疮寄生虫。

规格	价格	库存
50 mg	¥ 145	现货
100 mg	¥ 192	现货
500 mg	¥ 415	现货
1 g	¥ 597	现货
1 mL x 10 mM (in DMSO)	¥ 161	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.38%

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产品介绍

Crotamiton AI Summary

Crotamiton demonstrates a versatile range of bioactivities. It functions as both an activator and inhibitor of Cytochrome P450 3A4 with a potency of 12589.3 nM. In a screening assay for inhibitors of Chronic Active B-Cell Receptor Signaling, it shows inhibitory activity with a potency of 10000.0 nM. It also induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 398.1 nM. Further assays revealed that Crotamiton significantly inhibits OATP1B3 and OATP1B1 transporters, with 72.95% and 71.83% inhibition respectively, each at 10 µM concentration. It also exhibits bioactivity as an inhibitor of human BSEP, with an IC50 value of 109500.0 nM. Regarding antiviral activities, Crotamiton showed low activity in inhibiting viability of Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.2926, and also achieved a low hit score of 0.08702 against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells. Its IC50 value for inhibiting SARS-CoV-2 induced cytotoxicity of VERO-6 cells was greater than 20000.0 nM. In addition, the compound exhibits slight antifungal and antibacterial activities, with inhibition rates up to 21.1% against various bacterial strains, including Escherichia coli and Staphylococcus aureus MRSA. However, it has minimal effects against Candida albicans and Cryptococcus neoformans. The compound also impacts several physiological parameters such as electrolyte balance, kidney and liver function markers, and blood cell counts. Overall, Crotamiton is notable for its broad spectrum of biological effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Crotamiton (Eurax) is an antipruritic and a scabicidal agent available as a lotion or cream for topical use only. It is a colorless to slightly yellowish oil with a faint amine-like odor. It is miscible with methanol and with alcohol.
别名	克罗米通, Veteusan, Eurax, Crotamitone

化学信息

分子量	203.28
分子式	C₁₃H₁₇NO
CAS No.	483-63-6
Smiles	N(C(C=CC)=O)(CC)C1=C(C)C=CC=C1
密度	1.014 g/cm3

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (245.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (16.23 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9193 mL	24.5966 mL	49.1932 mL	245.9662 mL
5 mM	0.9839 mL	4.9193 mL	9.8386 mL	49.1932 mL
10 mM	0.4919 mL	2.4597 mL	4.9193 mL	24.5966 mL
20 mM	0.2460 mL	1.2298 mL	2.4597 mL	12.2983 mL
50 mM	0.0984 mL	0.4919 mL	0.9839 mL	4.9193 mL
100 mM	0.0492 mL	0.2460 mL	0.4919 mL	2.4597 mL