规格

价格

库存

数量

1 mg

¥ 1,300

现货

5 mg

¥ 2,920

现货

10 mg

¥ 4,320

现货

25 mg

¥ 6,880

现货

50 mg

¥ 9,330

现货

100 mg

¥ 12,500

现货

1 mL x 10 mM (in DMSO)

¥ 3,520

现货

生物活性

产品描述	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
靶点活性	PDE5A:3.6 nM, PDE1A:9.1 μM
体外活性	In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].
体内活性	In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].
别名	吉沙那非, UK-369003

化学信息

分子量	519.62
分子式	C₂₃H₃₃N₇O₅S
CAS No.	334826-98-1
Smiles	C(C)C1=C2C(=NN1CCOC)C(=O)N=C(N2)C3=C(OCC)N=CC(S(=O)(=O)N4CCN(CC)CC4)=C3
密度	1.41 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (105.85 mM), Sonication is recommended.

溶液配制表

DMSO