Carbidopa monohydrate

Name: Carbidopa monohydrate
Brand: TargetMol
SKU: T2148
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.30%

货号 T2148Cas号 38821-49-7

别名 卡比多巴水合物, S(-)-Carbidopa, Carbidopa Hydrate

Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。

Carbidopa monohydrate

一键复制产品信息

很棒

纯度: 98.30%

货号 T2148 别名 卡比多巴水合物, S(-)-Carbidopa, Carbidopa HydrateCas号 38821-49-7

规格	价格	库存
200 mg	¥ 118	现货
500 mg	¥ 198	现货
1 g	¥ 289	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.30%

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Carbidopa monohydrate AI Summary

Carbidopa monohydrate exhibits a broad spectrum of bioactivities and pharmacological properties. It shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 10000.0 nM to 12589.25 nM after 72 hours, as measured by SYBR green assays. It demonstrates uncompetitive inhibition of JMJD2E relative to alpha-ketoglutarate with a Ki value of 1980.0 nM, and inhibits Protein Tyrosine Kinase enzymes Fyn and LCK, with IC50 values of 3731.0 nM and 6795.0 nM, respectively. Furthermore, it inhibits the interaction between HIV1 integrase and LEDGF-75 with an IC50 value of 6540.0 nM. The compound also shows significant inhibition of sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells by 134.52% and 113.15%, respectively, at a 10 uM concentration. However, it has a moderate liver toxicity profile, presenting risks such as cholestasis, steatosis, and potentially acute liver toxicity, although conditions like cirrhosis and tumor formation have not been prominently observed. Testing against the FDA Liver Toxicity Knowledge Base Benchmark Dataset resulted in a DILI severity score of 4.0, though outcomes vary across other datasets. Carbidopa monohydrate influences a range of biological markers, including liver and kidney function, electrolyte balance, blood cell counts, blood proteins, glucose levels, and lipid metabolism. The compound's diverse bioactivities and high solubility in a 0.1 M phosphate buffer at pH 7.4 establish its potential as a candidate for various therapeutic investigations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
别名	卡比多巴水合物, S(-)-Carbidopa, Carbidopa Hydrate

化学信息

分子量	244.24
分子式	C₁₀H₁₆N₂O₅
CAS No.	38821-49-7
Smiles	CC(CC1=CC=C(O)C(O)=C1)(NN)C(O)=O
密度	1.42 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 5.5 mg/mL (22.52 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	204.7167 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
20 mM	0.2047 mL	1.0236 mL	2.0472 mL	10.2358 mL