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Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂;一种促智剂和晚期糖基化终产物 (AGE) 抑制剂,具有治疗阿尔茨海默病 (AD) 的潜力。
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Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂;一种促智剂和晚期糖基化终产物 (AGE) 抑制剂,具有治疗阿尔茨海默病 (AD) 的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 541 | In stock | |
5 mg | ¥ 1,220 | In stock | |
10 mg | ¥ 1,810 | In stock | |
25 mg | ¥ 2,890 | In stock | |
50 mg | ¥ 3,910 | In stock | |
100 mg | ¥ 5,250 | In stock | |
200 mg | ¥ 6,900 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 931 | In stock |
产品描述 | Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment. |
体外活性 | In vitro, tenilsetam inhibited endothelial proliferation at lower doses, while inducing apoptosis at high doses.?Leucocyte adhesion was only inhibited at high doses.?Sprouting angiogenesis of bovine retinal endothelial cells was promoted at lower doses (<?or = 10 mM).?At micromolar concentrations, endothelial VEGF expression was upregulated by 100%.?Long-term treatment with the AGE-inhibitor and iron-chelating compound tenilsetam inhibits the formation of acellular capillaries without correcting pericyte loss.?The compound has dose-dependent effects on endothelial cell function. |
别名 | 替尼西坦, Piperazinone |
分子量 | 182.24 |
分子式 | C8H10N2OS |
CAS No. | 86696-86-8 |
Smiles | O=C1NCCNC1C1=CC=CS1 |
密度 | 1.225g/cm3 |
颜色 | White |
物理性状 | Solid |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (137.18 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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