Betahistine

Name: Betahistine
Brand: TargetMol
SKU: T4195
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T4195Cas号 5638-76-6

别名 倍他司汀, Vasomotal, Serc base, PT 9 base

Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。

Betahistine

一键复制产品信息

很棒

纯度: 99.87%

货号 T4195 别名 倍他司汀, Vasomotal, Serc base, PT 9 baseCas号 5638-76-6

Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。

规格	价格	库存	数量
100 mg	¥ 133	现货
1 mL x 10 mM (in DMSO)	¥ 188	现货

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产品介绍

Betahistine AI Summary

Betahistine exhibits a contractile effect on isolated guinea pig ileal segments, indicating H1 receptor agonistic activity with a relative activity of 8.0% compared to histamine. It also has a binding affinity to the rat histamine H3 receptor with a Ki value of 2030.0 nM. The compound appears to pose a low risk of causing drug-induced liver injury, as assay results for multiple hepatic side effects yield a combined score of 0.0, suggesting minimal liver toxicity. Additionally, Betahistine affects various organ system functions and metabolic parameters, including liver and kidney function markers, electrolyte balance, and hematological parameters. It shows antiviral activity against SARS-CoV-2 with a hit score of 0.1802 in HRCE cells and an IC50 value greater than 20000.0 nM for cytotoxicity inhibition in VERO-6 cells, indicating moderate to weak antiviral efficacy. Furthermore, the compound did not exhibit significant inhibition or binding affinity for other tested targets in in vitro assays, with AC50 values greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.
别名	倍他司汀, Vasomotal, Serc base, PT 9 base

化学信息

分子量	136.19
分子式	C₈H₁₂N₂
CAS No.	5638-76-6
Smiles	CNCCC1=NC=CC=C1
密度	0.984 g/cm3. Temperature:25 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (220.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.69 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3427 mL	36.7134 mL	73.4268 mL	367.1342 mL
5 mM	1.4685 mL	7.3427 mL	14.6854 mL	73.4268 mL
10 mM	0.7343 mL	3.6713 mL	7.3427 mL	36.7134 mL
20 mM	0.3671 mL	1.8357 mL	3.6713 mL	18.3567 mL
50 mM	0.1469 mL	0.7343 mL	1.4685 mL	7.3427 mL
100 mM	0.0734 mL	0.3671 mL	0.7343 mL	3.6713 mL