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Prothionamide

Name: Prothionamide
Brand: TargetMol
SKU: T1161
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.34%

货号 T1161Cas号 14222-60-7

别名 丙硫异烟胺, Protionamide, 1321-TH

Prothionamide (1321-TH) 是一种具有抗结核活性的硫代酰胺衍生物。它可作用于结核病和麻风病。

Prothionamide

一键复制产品信息

很棒

纯度: 99.34%

货号 T1161 别名 丙硫异烟胺, Protionamide, 1321-THCas号 14222-60-7

Prothionamide (1321-TH) 是一种具有抗结核活性的硫代酰胺衍生物。它可作用于结核病和麻风病。

规格	价格	库存	数量
200 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.34%

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COA LCMS HNMR 产品操作手册

产品介绍

Prothionamide AI Summary

Prothionamide is a multifaceted bioactive molecule displaying various pharmacological effects. It shows strong inhibitory activity against several targets such as the malarial parasite plastid (potency of 82.8 nM), Mycobacterium tuberculosis (IC50 of 6610.0 nM in 7H9 media and enhanced activity with MIC50 values reduced up to 500.0 nM in the presence of specific inhibitors), and the enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 29092.9 nM. Additionally, it serves as an agonist for the Thyroid Stimulating Hormone Receptor with a potency of 31622.8 nM and an activator of Cytochrome P450 3A4 at 39810.7 nM. Clinically significant liver toxicity has been observed, indicated by elevated serum ALT and AST levels. The compound shows moderate hepatotoxicity with a rating of 8.0 and a highest observed frequency of 13.0% during trials. Acute liver toxicity was noted with a hepatic rating of 7.0 and a 2.5% highest frequency rate. Cytolytic liver toxicity is reported with a rating of 4.0, while no significant cholestatic liver toxicity is observed (rating of 0.0). Prothionamide also exhibits antiviral properties, specifically against SARS-CoV-2, inhibiting viral cytotoxicity in Vero E6 cells and Caco-2 cells at various concentrations. However, the efficacy varies, with inhibition scores ranging from 0.1% to over 30%, and an IC50 value exceeding 19952.62 nM, indicating moderate antiviral potency. Furthermore, it shows potential inhibitory activity against the SARS-CoV-2 3CL-Pro protease, though with an inhibition rate of -2.174% at 20µM suggesting a need for optimization. The compound demonstrates notable antimycobacterial activity against both standard and GFP expressing strains of Mycobacterium tuberculosis, especially in combination with EthR inhibitors, and has a minimum inhibitory concentration of 0.3 ug/mL for a strain harboring the inhA gene. Additionally, as a tyrosinase inhibitor, Prothionamide inhibits both mushroom tyrosinase and tyrosinase in mouse B16F10 cells, showing non-competitive inhibition and binding affinity. It also shows cytotoxicity against these cells at specific concentrations. Overall, Prothionamide is versatile with applications ranging from antimicrobial and anti-parasitic to antiviral activities, with significant liver safety considerations that must be carefully managed in clinical settings..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.
别名	丙硫异烟胺, Protionamide, 1321-TH

化学信息

分子量	180.27
分子式	C₉H₁₂N₂S
CAS No.	14222-60-7
Smiles	CCCC1=NC=CC(=C1)C(N)=S
密度	1.1015 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 7 mg/mL (38.83 mM), Sonication is recommended.

DMSO: 55 mg/mL (305.1 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.09 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5472 mL	27.7362 mL	55.4723 mL	277.3617 mL
5 mM	1.1094 mL	5.5472 mL	11.0945 mL	55.4723 mL
10 mM	0.5547 mL	2.7736 mL	5.5472 mL	27.7362 mL
20 mM	0.2774 mL	1.3868 mL	2.7736 mL	13.8681 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1109 mL	0.5547 mL	1.1094 mL	5.5472 mL
100 mM	0.0555 mL	0.2774 mL	0.5547 mL	2.7736 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Prothionamide Inhibitor inhibit Bacterial Antibiotic

Prothionamide

Prothionamide

Prothionamide 相关产品

产品介绍

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体内实验配液计算器

剂量转换

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