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Hydroxyzine Pamoate

Name: Hydroxyzine Pamoate
Brand: TargetMol
SKU: T0053
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.49%

货号 T0053Cas号 10246-75-0

别名 双羟萘酸羟嗪, Hydroxyzine embonate, Equipose, Bobsule

Hydroxyzine Pamoate (Bobsule) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。

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Hydroxyzine Pamoate

一键复制产品信息

很棒

纯度: 99.49%

货号 T0053 别名 双羟萘酸羟嗪, Hydroxyzine embonate, Equipose, BobsuleCas号 10246-75-0

Hydroxyzine Pamoate (Bobsule) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。

规格	价格	库存
2 mg	¥ 127	现货
5 mg	¥ 189	现货
10 mg	¥ 258	现货
25 mg	¥ 413	现货
50 mg	¥ 662	现货
100 mg	¥ 1,060	现货
200 mg	¥ 1,570	现货
1 mL x 10 mM (in DMSO)	¥ 293	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.49%

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COA LCMS HNMR 产品操作手册

产品介绍

Hydroxyzine Pamoate AI Summary

Hydroxyzine Pamoate exhibits a broad spectrum of bioactivities, demonstrating potency in inhibiting multiple targets and pathways. The compound is effective in inhibiting hydroxysteroid dehydrogenase 4, tau fibril formation, Cruzain, fructose-1,6-bisphosphate aldolase, histone lysine methyltransferase G9a, Bacillus subtilis Sfp phosphopantetheinyl transferase, Cytochrome P450 3A4, and Menin-MLL interaction, among others. It shows modest antiviral activity against the hepatitis C virus, Marburg virus, vaccinia orthopoxvirus, and SARS-CoV-2, where it inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, though with varying degrees of effectiveness. Additionally, Hydroxyzine Pamoate inhibits the SARS-CoV-2 3CL-Pro protease by 29.11% at a concentration of 20µM as determined via a FRET-based peptide substrate assay. Furthermore, Hydroxyzine Pamoate modulates the activity of OATP1B1 and OATP1B3 transporters in sodium fluorescein uptake assays, indicating potential as an OATP transporter modulator. The compound also displays antibacterial properties against multiple bacterial strains including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus (MRSA), with inhibition percentages ranging from 0.33% to 25.25%. It also shows antifungal activity against Candida albicans and Cryptococcus neoformans, albeit with lower inhibition rates. These diverse bioactivities suggest Hydroxyzine Pamoate has significant therapeutic potential across various infectious and non-infectious diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
别名	双羟萘酸羟嗪, Hydroxyzine embonate, Equipose, Bobsule

化学信息

分子量	763.27
分子式	C₄₄H₄₃ClN₂O₈
CAS No.	10246-75-0
Smiles	OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1.OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
密度	1.182g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (36.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.62 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3102 mL	6.5508 mL	13.1015 mL	65.5076 mL
5 mM	0.2620 mL	1.3102 mL	2.6203 mL	13.1015 mL
10 mM	0.1310 mL	0.6551 mL	1.3102 mL	6.5508 mL
20 mM	0.0655 mL	0.3275 mL	0.6551 mL	3.2754 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。