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URAT1 inhibitor 7

Name: URAT1 inhibitor 7
Brand: TargetMol
SKU: T77517
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T77517Cas号 1632002-28-8 一键复制产品信息纯度: 97.14%

很棒

URAT1 inhibitor 7 是一种新型高效的人尿酸转运蛋白 URAT1 抑制剂 (IC50:12 nM)。URAT1 inhibitor 7 对 CYP2C9 具有抑制作用，IC50为4.2 μM。URAT1 inhibitor 7 可用于研究高尿酸血症和痛风。

URAT1 inhibitor 7

一键复制产品信息

很棒

纯度: 97.14%

货号 T77517Cas号 1632002-28-8

规格	价格	库存
1 mg	¥ 1,300	现货
5 mg	¥ 3,250	现货
10 mg	¥ 4,750	现货
25 mg	¥ 7,480	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,600	现货
500 mg	¥ 27,300	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.14%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

URAT1 inhibitor 7 AI Summary

URAT1 inhibitor 7 exhibits a wide range of bioactivities. It has a renal clearance of 0.0001 mL.min-1.kg-1 in both dogs and rats, and an oral bioavailability of 100.0% in rats at various doses. The volume of distribution at steady state in rats varies between 0.18 and 0.25 L.kg-1, with a half-life ranging from 6.7 to 7.1 hours. The compound shows unbound clearance rates between 95.0 and 229.0 mL.min-1.kg-1 and a plasma clearance of 0.39 mL.min-1.kg-1 in rats. It inhibits enzymes such as CYP2D6, CYP2C19, CYP2C9, and CYP2C8, with IC50 values ranging from 4200.0 to 17500.0 nM. In terms of cytotoxicity, URAT1 inhibitor 7 has an activity of 103.0 uM against THLE cells. It inhibits transporters like OAT4, OAT3, and OAT1 with IC50 values between 720.0 and 14000.0 nM and has a low fraction unbound in plasma. The compound's solubility is 7700.0 nM at pH 6.5. Toxicity assessments show an MTD of 100.0 mg kg-1 in po dosed rats and activity ≤ 300.0 mg kg-1 in po dosed dogs. URAT1 inhibitor 7 also inhibits the GABAA receptor with a Ki value of 4800.0 nM and exhibits substrate activity at BCRP and p-gp, with efflux ratios of 122.0 and 3.5, respectively. Additionally, URAT1 inhibitor 7 has shown an IC50 value of 13.0 nM in an inhibition assay and demonstrates inhibitory activity on uric acid transport within the 0 to 10 uM concentration range, pre-incubated and compared against a vehicle (DMSO) and a pharmacological blockade (benzbromarone)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.

化学信息

分子量	428.82
分子式	C₁₉H₁₀ClFN₄O₃S
CAS No.	1632002-28-8
Smiles	N#CC1=CC=C(OC2=CC=C(C=C2C#N)S(=O)(=O)NC3=NC=C(F)C=C3)C=C1Cl
密度	1.58 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (116.6 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3320 mL	11.6599 mL	23.3198 mL	116.5990 mL
5 mM	0.4664 mL	2.3320 mL	4.6640 mL	23.3198 mL
10 mM	0.2332 mL	1.1660 mL	2.3320 mL	11.6599 mL
20 mM	0.1166 mL	0.5830 mL	1.1660 mL	5.8300 mL
50 mM	0.0466 mL	0.2332 mL	0.4664 mL	2.3320 mL
100 mM	0.0233 mL	0.1166 mL	0.2332 mL	1.1660 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。