BI 01383298

Name: BI 01383298
Brand: TargetMol
SKU: T5324
Price: 112 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.71%

货号 T5324Cas号 2227549-00-8

BI 01383298 是肝脏中高度表达的柠檬酸钠协同转运蛋白抑制剂。

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BI 01383298

一键复制产品信息

很棒

纯度: 99.71%

货号 T5324Cas号 2227549-00-8

BI 01383298 是肝脏中高度表达的柠檬酸钠协同转运蛋白抑制剂。

规格	价格	库存
1 mg	¥ 112	现货
5 mg	¥ 260	现货
10 mg	¥ 457	现货
25 mg	¥ 931	现货
50 mg	¥ 1,370	现货
100 mg	¥ 2,020	现货
200 mg	¥ 2,890	现货
1 mL x 10 mM (in DMSO)	¥ 287	现货

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产品介绍

BI 01383298 AI Summary

BI 01383298 demonstrates cell-type-specific bioactivities impacting cell viability and protein thermal stability. In terms of cell viability, the compound shows varying effects: in HEK293T cells, growth rates range from negative (-0.42) to positive (up to 0.95); in U2OS cells, growth rates are consistently positive, ranging from 0.72 to 0.98; and in human fibroblasts, the growth rates vary between 0.3 and 0.84. This suggests that the compound can either inhibit or promote cell growth depending on the cell type. In protein thermal stability assays, BI 01383298 exhibits domain-specific effects with some domains showing increased stability (positive Delta TM values) and others decreased stability (negative Delta TM values). Specific domains such as M1-K294 and E122-S403 display increased stability, while domains like M1-L298 and M26-R383 exhibit decreased stability, indicating variable interaction kinetics across different protein regions. Additionally, BI 01383298 shows significant bioactivity in affinity-based cellular interactions, particularly targeting the citrate uptake inhibition assay in HepG2 cells expressing endogenous SLC13A5, with an IC50 value of 24.0 nM. Another report shows an IC50 value of 56.0 nM for the same assay. The compound also interacts with OPRK1, exhibiting 19.0% of control in the SafetyScreen44™ assay, indicating selective modulatory effects on this target..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).

化学信息

分子量	445.34
分子式	C₁₉H₁₉Cl₂FN₂O₃S
CAS No.	2227549-00-8
Smiles	Fc1ccc(CNC(=O)C2CCN(CC2)S(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1
密度	1.419 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22 mg/mL (49.4 mM), Sonication is recommended.

H2O: Insoluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2455 mL	11.2274 mL	22.4548 mL	112.2738 mL
5 mM	0.4491 mL	2.2455 mL	4.4910 mL	22.4548 mL
10 mM	0.2245 mL	1.1227 mL	2.2455 mL	11.2274 mL
20 mM	0.1123 mL	0.5614 mL	1.1227 mL	5.6137 mL