Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays <5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 4,670 | 35日内发货 | ||
50 mg | ¥ 19,600 | 35日内发货 |
LY 2886721 Hydrochloride 的其他形式现货产品:
产品描述 | Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model. |
分子量 | 426.87 |
分子式 | C18H17ClF2N4O2S |
CAS No. | 1262036-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.69 mg/mL(100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3426 mL | 11.7132 mL | 23.4263 mL | 58.5658 mL |
5 mM | 0.4685 mL | 2.3426 mL | 4.6853 mL | 11.7132 mL | |
10 mM | 0.2343 mL | 1.1713 mL | 2.3426 mL | 5.8566 mL | |
20 mM | 0.1171 mL | 0.5857 mL | 1.1713 mL | 2.9283 mL | |
50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
100 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5857 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LY 2886721 Hydrochloride 1262036-49-6 LY2886721 Hydrochloride LY-2886721 Hydrochloride Inhibitor inhibitor inhibit