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Nateglinide

Name: Nateglinide
Brand: TargetMol
SKU: T1674
Price: 109 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T1674Cas号 105816-04-4

别名 那格列奈, Senaglinide, A4166

Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物，是口服有效的、短效促胰岛素释放化合物，也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。

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Nateglinide

一键复制产品信息

很棒

纯度: 99.94%

货号 T1674 别名 那格列奈, Senaglinide, A4166Cas号 105816-04-4

规格	价格	库存
2 mg	¥ 109	现货
5 mg	¥ 169	现货
10 mg	¥ 238	现货
25 mg	¥ 467	现货
50 mg	¥ 762	现货
100 mg	¥ 1,400	现货
200 mg	¥ 1,850	现货
1 mL x 10 mM (in DMSO)	¥ 326	现货

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纯度: 99.93%

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产品介绍

Nateglinide AI Summary

Nateglinide exhibits a range of bioactivities and pharmacokinetic properties. It has notable hypoglycemic activity, reducing blood glucose levels by more than 20% in fasting mice at a dose of 1.6 mg kg^-1 and shows insulin-releasing activity in HIT-T15 cells in high glucose conditions, with activity levels ranging from 36.3% to 124.3% across different concentrations (1 µM, 10 µM, 100 µM). The EC50 for insulin-releasing activity is 7590.0 nM. Pharmacokinetically, Nateglinide demonstrates high bioavailability (F_fraction = 0.72) and good absorption (Fa = 0.9) in humans. It has moderate hepatic (CL = 1.7 mL/min/kg) and renal clearance (CL_renal = 0.1 mL/min/kg) rates, a steady-state volume of distribution (Vdss) of 0.15 L/kg, and an elimination half-life (T1/2) of 1.5 hours. Nateglinide shows inhibitory effects on several transport and enzyme activities. It inhibits OATP1B3 and OATP1B1 transport proteins significantly, with 70.33% and 99.81% inhibition respectively at 10 µM, and also shows inhibitory activity on several transport protein assays, including MRP3 (IC50 = 104000.0 nM). Additionally, Nateglinide displays antiviral activities against SARS-CoV-2, showing an inhibition index of 0.7846 in Vero E6 cells and 2.79% inhibition rate in Caco-2 cells at 10 µM. It inhibits the SARS-CoV-2 3CL-Pro protease by 7.842% at 20 µM and shows some cell viability effects. It also exhibits moderate antihyperglycemic activity in diabetic rats with significant blood glucose reductions at 30.6%, 26.4%, and 13.8% at different time intervals post-administration. Furthermore, it affects various biomarker levels related to liver and kidney functions as well as having potential antifungal and antibacterial activities against Candida albicans, Cryptococcus neoformans, and bacterial strains like E. coli, K. pneumoniae, and S. aureus MRSA. Lastly, Nateglinide's pharmacological profile includes liver toxicity, indicated by a severity class index of 3.0, and potential bioactivity in modulating drug-induced liver injury processes. It also shows significant impacts on insulin secretion, with varying IC50 values under different glucose conditions in INS-1E cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare instances of clinically apparent acute liver injury.
别名	那格列奈, Senaglinide, A4166

化学信息

分子量	317.42
分子式	C₁₉H₂₇NO₃
CAS No.	105816-04-4
Smiles	C(N[C@H](CC1=CC=CC=C1)C(O)=O)(=O)[C@H]2CC[C@H](C(C)C)CC2
密度	1.104 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (189.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.3 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1504 mL	15.7520 mL	31.5040 mL	157.5200 mL
5 mM	0.6301 mL	3.1504 mL	6.3008 mL	31.5040 mL
10 mM	0.3150 mL	1.5752 mL	3.1504 mL	15.7520 mL
20 mM	0.1575 mL	0.7876 mL	1.5752 mL	7.8760 mL
50 mM	0.0630 mL	0.3150 mL	0.6301 mL	3.1504 mL
100 mM	0.0315 mL	0.1575 mL	0.3150 mL	1.5752 mL