Zoledronic acid monohydrate

Name: Zoledronic acid monohydrate
Brand: TargetMol
SKU: T21299
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.91%

货号 T21299Cas号 165800-06-6

别名 唑来膦酸一水合物, Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446

Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐，具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡，有抗癌作用。

Zoledronic acid monohydrate

一键复制产品信息

很棒

纯度: 99.91%

货号 T21299 别名 唑来膦酸一水合物, Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446Cas号 165800-06-6

Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐，具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡，有抗癌作用。

规格	价格	库存
2 mg	¥ 133	现货
5 mg	¥ 196	现货
10 mg	¥ 283	现货
25 mg	¥ 455	现货
50 mg	¥ 662	现货
100 mg	¥ 993	现货
500 mg	¥ 1,380	现货

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纯度: 99.91%

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COA HNMR LCMS 产品操作手册

产品介绍

Zoledronic acid monohydrate AI Summary

Zoledronic acid monohydrate is a multifaceted agent demonstrating significant bioactivities across various biological systems. Notably, it exhibits potent inhibition of osteoclastic bone resorption in rats with an effective dose of 0.0001 mg/kg and an IC50 of 0.2399 nM. The compound shows strong inhibitory activity against human recombinant FPPS (Farnesyl Pyrophosphate Synthase) with an IC50 of 3.0 nM to 4.1 nM, suggesting its potential for therapeutic applications in bone metabolism-related conditions. Additionally, Zoledronic acid monohydrate has antiproliferative effects on various cancer cell lines, including human KB (nasopharyngeal carcinoma) cells with an LD50 of 63.7 µM and other cancer cell lines with IC50 values ranging from 10000.0 nM to 61582.0 nM. It inhibits human Gamma delta T cells, human GGPPS, and demonstrates cytotoxicity against RPMI8226 cells with an EC50 of 11000.0 nM after 72 hours. The compound also presents antimicrobial properties, inhibiting the growth of Entamoeba histolytica (IC50 of 12000.0 nM), Plasmodium falciparum (IC50 of up to 167000.0 nM), Leishmania major FPPS (Ki of 11.0 nM), Toxoplasma gondii FPPS (IC50 of 70.0 nM), and Trypanosoma brucei. It shows selective toxicity toward certain human cancer cells like BXPC-3, CFPAC-1, and PANC-1, with similar IC50 values of 10000.0 nM. Moreover, Zoledronic acid monohydrate has shown antiviral activity against SARS-CoV-2 by inhibiting its induced cytotoxicity in VERO-6 cells. It exerts inhibitory effects on multiple human recombinant carbonic anhydrase isoforms (CA1, CA2, CA9, CA12, CA14) with IC50 values as low as 62.0 nM. In summary, Zoledronic acid monohydrate demonstrates a broad spectrum of bioactivities including bone resorption inhibition, antiproliferative effects on cancer cells, antimicrobial and antiviral properties, and inhibition of various enzymes critical for disease mechanisms..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
别名	唑来膦酸一水合物, Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446

化学信息

分子量	290.1
分子式	C₅H₁₂N₂O₈P₂
CAS No.	165800-06-6
Smiles	OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H]
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 1 mg/mL (insoluble or slightly soluble)

0.1M NaOH: 10 mg/mL (34.47 mM), Sonication and heating are recommended.

H2O: Insoluble

溶液配制表

0.1M NaOH

	1mg	5mg	10mg	50mg
1 mM	3.4471 mL	17.2354 mL	34.4709 mL	172.3544 mL
5 mM	0.6894 mL	3.4471 mL	6.8942 mL	34.4709 mL
10 mM	0.3447 mL	1.7235 mL	3.4471 mL	17.2354 mL
20 mM	0.1724 mL	0.8618 mL	1.7235 mL	8.6177 mL