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Memantine hydrochloride

Name: Memantine hydrochloride
Brand: TargetMol
SKU: T1443
Price: 331 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.96%

货号 T1443Cas号 41100-52-1

别名 盐酸美金刚, Namenda, Memantine HCl, D-145 (hydrochloride), 3,5-二甲基金刚胺盐酸盐

Memantine hydrochloride (Memantine HCl) 是一种具有一些多巴胺能作用的金刚烷胺衍生物，是一种温和的 NMDA 受体非竞争性拮抗剂，能够抑制 CYP2B6 和 CYP2D6。它可作为抗帕金森剂。

Memantine hydrochloride

一键复制产品信息

很棒

纯度: 99.96%

货号 T1443 别名 盐酸美金刚, Namenda, Memantine HCl, D-145 (hydrochloride), 3,5-二甲基金刚胺盐酸盐Cas号 41100-52-1

规格	价格	库存	数量
500 mg	¥ 331	现货
1 g	¥ 471	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.96%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
靶点活性	CYP2B6:0.51 nM(Ki), CYP2D6:94.9 μM(Ki)
别名	盐酸美金刚, Namenda, Memantine HCl, D-145 (hydrochloride), 3,5-二甲基金刚胺盐酸盐

化学信息

分子量	215.76
分子式	C₁₂H₂₂ClN
CAS No.	41100-52-1
Smiles	Cl.[H][C@]12C[C@]3(C)C[C@](C)(C1)C[C@](N)(C2)C3
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (579.35 mM), Sonication is recommended.

H2O: 28 mg/mL (129.77 mM), Sonication is recommended.

Ethanol: 40 mg/mL (185.39 mM), Sonication is recommended.

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6348 mL	23.1739 mL	46.3478 mL	231.7390 mL
5 mM	0.9270 mL	4.6348 mL	9.2696 mL	46.3478 mL
10 mM	0.4635 mL	2.3174 mL	4.6348 mL	23.1739 mL
20 mM	0.2317 mL	1.1587 mL	2.3174 mL	11.5869 mL
50 mM	0.0927 mL	0.4635 mL	0.9270 mL	4.6348 mL
100 mM	0.0463 mL	0.2317 mL	0.4635 mL	2.3174 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Memantine hydrochloride demonstrates extensive bioactivity across a wide range of biological targets and disease models. It shows significant antiallodynic effects by increasing the paw withdrawal threshold in chronic sciatic nerve constriction injury rats from 2.8 g to 10.4 g after intraperitoneal administration of 60 mg/kg, indicating potential analgesic properties. The compound exhibits antiplasmodial activity against various Plasmodium falciparum strains, with IC50 values ranging from 1000.0 nM to 10000.0 nM over 72 hours, demonstrating potent antiparasitic effects. Additionally, Memantine hydrochloride has been identified as a modulator of multiple molecular targets, including inhibitors of APE1, AmpC Beta-Lactamase, and Neuropeptide S Receptor, among others. It also enhances the activity of the Vanilloid Receptor 1 and inhibits histone lysine methyltransferase G9a. The compound shows antiviral activity, such as inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells and exhibiting modest inhibition of SARS-CoV-2 3CL-Pro protease. However, its effectiveness against SARS-CoV-2 in VERO-6 cells was lower compared to a control antiviral agent. Memantine hydrochloride has antagonistic activity on rat brain GluN1/GluN2B and GluN1/GluN2A receptors, with IC50 values of 2099.0 nM and 1376.1 nM, respectively. It also displays antimicrobial activity against fungi like Candida albicans and bacteria such as Escherichia coli and Staphylococcus aureus MRSA, with varying degrees of inhibition. In cancer models, Memantine hydrochloride showed antiproliferative activity against human U-87 MG cells with an IC50 of 23590.0 nM and induced cell cycle arrest in human A 172 cells. These findings suggest that Memantine hydrochloride holds potential for multiple therapeutic applications, meriting further research and development..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl