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Rufloxacin hydrochloride

Name: Rufloxacin hydrochloride
Brand: TargetMol
SKU: TQ0221
Price: 295 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.80%

货号 TQ0221Cas号 106017-08-7

别名 盐酸芦氟沙星, MF-934 hydrochloride

Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种氟喹诺酮类抗菌剂，可抑制拓扑异构酶。 Rufloxacin hydrochloride 抑制人单核细胞中的 B 细胞分化。

Rufloxacin hydrochloride

一键复制产品信息

很棒

纯度: 99.80%

货号 TQ0221 别名 盐酸芦氟沙星, MF-934 hydrochlorideCas号 106017-08-7

Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种氟喹诺酮类抗菌剂，可抑制拓扑异构酶。 Rufloxacin hydrochloride 抑制人单核细胞中的 B 细胞分化。

规格	价格	库存
25 mg	¥ 295	现货
50 mg	¥ 417	现货
100 mg	¥ 671	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial and inhibits topoisomerase. Rufloxacin hydrochloride inhibits B-cell differentiation in human mononuclear cells.
别名	盐酸芦氟沙星, MF-934 hydrochloride

化学信息

分子量	399.867
分子式	C₁₇H₁₉ClFN₃O₃S
CAS No.	106017-08-7
Smiles	Cl.CN1CCN(CC1)c1c(F)cc2c3c1SCCn3cc(C(O)=O)c2=O
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 1 mg/mL (2.5 mM), Sonication is recommended. DMSO: 0.08 mg/mL (0.2 mM), Sonication and heating are recommended.

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Rufloxacin hydrochloride shows bioactivity across a spectrum of biological assays targeting various enzymes and pathogens. It exhibits nanomolar potency in inhibiting enzymes such as HSD17B4, JMJD2E, ALDH1A1, HPGD, HADH2, and the histone lysine methyltransferase G9a. The compound also demonstrates inhibitory activity against non-replicating, drug-tolerant Mycobacterium tuberculosis, the malarial parasite plastid, and specific regions in Salmonella Typhimurium and Salmonella typhi. Furthermore, Rufloxacin hydrochloride inhibits cellular entry mechanisms of the Ebola virus. In terms of antiviral activity, Rufloxacin hydrochloride shows efficacy against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells and VERO-6 cells at a concentration of 10 µM, with reported inhibition rates of 17.62% and 0.01% respectively after 48 hours. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 12.56% at a 20 µM concentration. Additionally, Rufloxacin hydrochloride displays antifungal activity against Candida albicans and Cryptococcus neoformans with MIC values greater than 10,000 nM. Its antibacterial activity spans various bacteria, including Escherichia coli (MIC 1,250 nM), Pseudomonas aeruginosa (MIC 10,000 nM), Staphylococcus aureus MRSA (MIC 2,500 nM), Klebsiella pneumoniae, and Acinetobacter baumannii (both with MIC values greater than 10,000 nM). It has a cytotoxicity (CC50) greater than 10,000 nM against HEK293 cells. Overall, Rufloxacin hydrochloride exhibits a broad range of bioactivities against enzymes, pathogens, and viruses..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl