Chk

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.

Cat. No.	Product Name	CAS No.	Purity
T10325	ANI-7 化合物ANI-7	931417-26-4	98%
T10325	ANI-7是芳香烃受体（AhR）途径的激活剂。ANI-7抑制多种癌症细胞的生长，并有效且选择性地抑制MCF-7乳腺癌症细胞的生长（GI50:0.56μM）。
T10792L	CHK1-IN-4 hydrochloride 化合物CHK1-IN-4盐酸盐		98%
T10792L	CHK1-IN-4 hydrochloride 是有效的checkpoint kinase 1 (chk1) 抑制剂，对肿瘤细胞中 chk1 磷酸化具有有效的抑制作用。CHK1-IN-4 hydrochloride 显示出抗肿瘤活性。
T10718L	CCT241533 hydrochloride 化合物 T10718L	1431697-96-9	98%
T10718L	CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
TN1458	Buddlejasaponin IV 醉鱼草皂苷 Ⅳ	139523-30-1	98%
TN1458	Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
T17223	VER-00158411 化合物 T17223	1174664-88-0	98%
T17223	VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
T16165	Myriocin 多球壳菌素	35891-70-4	98%
T16165	Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-pal...
T10790	CHK1-IN-2 化合物 T10790	912367-45-4	98%
T10790	CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
T16848	SB-218078 化合物 T16848	135897-06-2	98%
T16848	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T13148	CHK-IN-1 化合物 T13148	1278405-51-8	98%
T13148	CHK-IN-1 is a CHK1 and CHK2 inhibitor, has anti-proliferative activities.
T10793	CHK1 inhibitor 化合物 T10793	2097938-64-0	98%
T10793	CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
T10718	CCT241533 化合物 T10718	1262849-73-9	98%
T10718	CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T14904	CCT244747 化合物 T14904	1404095-34-6	98%
T14904	CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
T10792	CHK1-IN-4 化合物 T10792	2120398-41-4	98%
T10792	CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
T11960	MBM-55 化合物MBM-55	2083622-09-5	98%
T11960	MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂，IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T9252	LY2880070 化合物LY2880070	1375637-35-6	98%
T9252	LY2880070 是一种用于癌症治疗的新型检查点激酶 1 (CHK1) 抑制剂。
T3700	SCH900776 (S-isomer) 化合物SCH900776 S-isomer	891494-64-7	98%
T3700	SCH900776 S-isomer 是SCH900776的S 型同分异构体。
T2485	Baricitinib 巴瑞克替尼	1187594-09-7	98%
T2485	Baricitinib 是一种选择性，可口服的JAK1和JAK2抑制剂，IC50分别为5.9 nM 和 5.7 nM，具有潜在的抗炎、免疫调节和抗肿瘤活性。
T10406	Tuvusertib 化合物Tuvusertib	1613200-51-3	98%
T10406	Tuvusertib 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂（Ki< 1 µΜ），具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性，阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK1)的下游磷酸化，从而抑制 DNA 损伤检查点激活，破坏 DNA 损伤修复，诱导肿...
T6931	PD0166285 化合物PD0166285	185039-89-8	98%
T6931	PD0166285是 P-gp 的底物，是一种有效的 Wee1 和 Chk1 抑制剂弱抑制。
T1837	BX-912 化合物BX912	702674-56-4	98%
T1837	BX-912 是一种直接的，选择性的，ATP 竞争性的PDK1抑制剂，IC50值为 26 nM。它阻断肿瘤细胞 PDK1/Akt 信号转导，抑制多种肿瘤细胞株的锚定依赖性生长或诱导凋亡。