TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research .

TEAD1:8.7 nM, TEAD2:3.4 nM, TEAD3:5.6 nM

TEAD-IN-11 在 MCF-7 报告基因实验中表现出优异的抑制活性 (IC50 ≤10 nM) [1]。该化合物对 TEAD1 和 TEAD2 具有出色的选择性，在 HEK293T 细胞中分别实现了 93% 和 95% 的抑制率 [1]。