Hydrocortisone hemisuccinate

Name: Hydrocortisone hemisuccinate
Brand: TargetMol
SKU: T4602
Price: 143 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.7%

货号 T4602Cas号 2203-97-6

别名 氢化可的松琥珀酸酯, hydrocortisone 21-hemisuccinate*free acid, Hydrocortisone 21-hemisuccinate, Hydrocortisone 21-he

Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素，是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性，可用于研究溃疡性结肠炎。

Hydrocortisone hemisuccinate

一键复制产品信息

很棒

纯度: 98.7%

货号 T4602 别名 氢化可的松琥珀酸酯, hydrocortisone 21-hemisuccinate*free acid, Hydrocortisone 21-hemisuccinate, Hydrocortisone 21-heCas号 2203-97-6

规格	价格	库存
10 mg	¥ 216	现货
25 mg	¥ 413	现货
50 mg	¥ 578	现货
100 mg	¥ 747	现货
500 mg	¥ 1,850	现货
1 mL x 10 mM (in DMSO)	¥ 143	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.7%

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Hydrocortisone hemisuccinate AI Summary

Hydrocortisone hemisuccinate was evaluated for various bioactivities and displays a range of biological effects. Specifically, it inhibits HIV-1 Protease with an IC50 value of 27.0 µM and shows activity in inhibiting the production of scrapie form PrP in mouse GT1-7 cells with an IC50 greater than 100,000 nM. It modulates glucocorticoid receptor activity with a Kd value of 190.0 nM in a mouse L929 cell assay. Hydrocortisone hemisuccinate also enhances SMN2 splice variant expression, acts as an agonist and antagonist for the hypoxia response element signaling pathway, and inhibits AmpC Beta-Lactamase, Nrf2, chronic active B-cell receptor signaling, and TGF-b. Additionally, it inhibits binding or entry of Lassa Virus into cells. In transporter assays, Hydrocortisone hemisuccinate significantly inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 101.77% and in OATP1B1-transfected CHO cells by 93.98% at 10 µM. The compound exhibits modest antifungal activity against Candida albicans and Cryptococcus neoformans and varied antibacterial activity with notable inhibition against Pseudomonas aeruginosa. However, it shows minor or negative inhibition against other bacterial strains like Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus. Comprehensive screening data suggest that Hydrocortisone hemisuccinate has low binding affinity and minimal inhibition across other human and rat receptors and enzymes, indicating limited interaction or modulation for those targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.
靶点活性	IL-3:21.4 μM (IC50), IL-6:6.7 μM (IC50)
别名	氢化可的松琥珀酸酯, hydrocortisone 21-hemisuccinate*free acid, Hydrocortisone 21-hemisuccinate, Hydrocortisone 21-he

化学信息

分子量	462.53
分子式	C₂₅H₃₄O₈
CAS No.	2203-97-6
Smiles	CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2(O)C(=O)COC(=O)CCC(O)=O
密度	1.33 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (529.7 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1620 mL	10.8101 mL	21.6202 mL	108.1011 mL
5 mM	0.4324 mL	2.1620 mL	4.3240 mL	21.6202 mL
10 mM	0.2162 mL	1.0810 mL	2.1620 mL	10.8101 mL
20 mM	0.1081 mL	0.5405 mL	1.0810 mL	5.4051 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1620 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0810 mL