规格

价格

库存

数量

1 mg

¥ 391

现货

5 mg

¥ 954

现货

10 mg

¥ 1,480

现货

25 mg

¥ 2,500

现货

50 mg

¥ 3,570

现货

100 mg

¥ 4,950

现货

1 mL x 10 mM (in DMSO)

¥ 1,190

现货

生物活性

产品描述	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
靶点活性	PKCβ2:163 nM, PKCγ:213 nM, PKCα:53 nM, PKC:158 nM(Rat Brain), PKCβ1:195 nM, PKCε:175 nM
体外活性	Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Bisindolylmaleimide VIII acetate (5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners. Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappears at 6 h after the combined treatment with TRA-8 [2].
体内活性	Bisindolylmaleimide VIII acetate (100 μg; i.p.; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The alone treatment with Bisindolylmaleimide VIII acetate does not induce significant tumor regression [2].
别名	Ro 31-7549 acetate, Bis VIII acetate

化学信息

分子量	458.51
分子式	C₂₆H₂₆N₄O₄
CAS No.	138516-31-1
Smiles	CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 150 mg/mL (327.15 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1810 mL	10.9049 mL	21.8098 mL	109.0489 mL
5 mM	0.4362 mL	2.1810 mL	4.3620 mL	21.8098 mL
10 mM	0.2181 mL	1.0905 mL	2.1810 mL	10.9049 mL
20 mM	0.1090 mL	0.5452 mL	1.0905 mL	5.4524 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1810 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0905 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Bisindolylmaleimide VIII acetate

Bisindolylmaleimide VIII acetate

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Bisindolylmaleimide VIII acetate

Bisindolylmaleimide VIII acetate