Name: IDX184
Brand: TargetMol
SKU: T27586
Price: 1330 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,330

现货

5 mg

¥ 3,360

现货

10 mg

¥ 4,890

现货

25 mg

¥ 7,680

现货

50 mg

¥ 9,870

现货

产品介绍

生物活性

产品描述	IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase.
靶点活性	HCV polymerase:52.3 nM (Ki), HCV polymerase:0.31 μM (IC50)
体外活性	IDX184, a liver-targeted prodrug of the nucleotide 2′-MeG-MP, serves as a hepatitis C virus polymerase inhibitor with liver-specific targeting.[1] IDX184 is not toxic (CC50>100μM) in any tested cell line.[2] IDX184 is a second-generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM).[2]
别名	IDX-184, IDX 184

化学信息

分子量	626.62
分子式	C₂₅H₃₅N₆O₉PS
CAS No.	1036915-08-8
Smiles	C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O
密度	1.59 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (79.79 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5959 mL	7.9793 mL	15.9586 mL	79.7932 mL
5 mM	0.3192 mL	1.5959 mL	3.1917 mL	15.9586 mL
10 mM	0.1596 mL	0.7979 mL	1.5959 mL	7.9793 mL
20 mM	0.0798 mL	0.3990 mL	0.7979 mL	3.9897 mL
50 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5959 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

IDX184

IDX184

产品介绍

计算器

体内实验配液计算器

剂量转换

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