Nylidrin hydrochloride

Name: Nylidrin hydrochloride
Brand: TargetMol
SKU: T0173
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 布芬宁盐酸盐, Buphenine HCl

货号 T0173Cas号 849-55-8 一键复制产品信息纯度: 99.35%

很棒

Nylidrin hydrochloride (Buphenine HCl) 是被动致敏大鼠腹腔肥大细胞中IgE 介导的组胺释放抑制剂，具有抗过敏的功效。它也是被动致敏的豚鼠肺切片中 IgG1 介导的组胺释放抑制剂。

Nylidrin hydrochloride

一键复制产品信息

很棒

纯度: 99.35%

货号 T0173Cas号 849-55-8

别名 布芬宁盐酸盐, Buphenine HCl

规格	价格	库存
5 mg	¥ 145	现货
10 mg	¥ 197	现货
25 mg	¥ 297	现货
50 mg	¥ 443	现货
100 mg	¥ 645	现货
500 mg	¥ 1,330	现货
1 mL x 10 mM (in DMSO)	¥ 163	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.35%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS 产品操作手册

产品介绍

Nylidrin hydrochloride AI Summary

Nylidrin hydrochloride exhibits a range of biological activities, showing efficacy against various targets. It has in vitro blocking activity against the alpha adrenergic receptor with a Kd of 616.6 nM and displays spasmolytic activity with a Kd of 4265.8 nM in isolated guinea pig ileum. In vivo, it significantly reduces systolic blood pressure in spontaneously hypertensive rats, achieving decreases of 54.0 mmHg after 1 hour and 51.0 mmHg after 4 hours, at a dose of 50 mg/kg peroral. Additionally, it shows antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 2511.89 nM to 12589.25 nM. The compound also demonstrates inhibitory effects in enzyme-related assays, including APE1, AmpC Beta-Lactamase, and BLM, with potency values spanning from 891.3 nM to 56234.1 nM. Furthermore, it exhibits virus inhibition activities against Marburg Virus and Hepatitis C Virus (HCV), and inhibits SARS-CoV-2 3CL-Pro protease with 30.36% inhibition at 20 µM. Nylidrin hydrochloride also inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, and displays antiviral effects against SARS-CoV-2 by reducing cytotoxicity in Caco-2 and VERO-6 cells, with inhibition percentages of 11.52% and 0.08%, respectively, at a concentration of 10 µM, determined by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nylidrin hydrochloride (Buphenine HCl) was an effective inhibitor of the IgG1-mediated release of histamine from passively sensitized guinea pig lung slices, and of the IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils.
别名	布芬宁盐酸盐, Buphenine HCl

化学信息

分子量	335.87
分子式	C₁₉H₂₆ClNO₂
CAS No.	849-55-8
Smiles	Cl.CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1
密度	no data available

储存&溶解度

存储

溶解度信息

DMSO: 60 mg/mL (178.64 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9773 mL	14.8867 mL	29.7734 mL	148.8671 mL
5 mM	0.5955 mL	2.9773 mL	5.9547 mL	29.7734 mL
10 mM	0.2977 mL	1.4887 mL	2.9773 mL	14.8867 mL
20 mM	0.1489 mL	0.7443 mL	1.4887 mL	7.4434 mL
50 mM	0.0595 mL	0.2977 mL	0.5955 mL	2.9773 mL
100 mM	0.0298 mL	0.1489 mL	0.2977 mL	1.4887 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。