Sulfacetamide

Name: Sulfacetamide
Brand: TargetMol
SKU: T21434
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.87%

货号 T21434Cas号 144-80-9

别名 磺胺醋酰, Sulphacetamide, Sebizon, Region, NSC-63871, NSC63871, NSC 63871, Acetosulfamine

Sulfacetamide (NSC-63871) 是一种抗生素，通过限制细菌生存所需的叶酸的存在来治疗睑缘炎或结膜炎，有潜力用于眼部感染的研究。

Sulfacetamide

一键复制产品信息

很棒

纯度: 99.87%

货号 T21434 别名 磺胺醋酰, Sulphacetamide, Sebizon, Region, NSC-63871, NSC63871, NSC 63871, AcetosulfamineCas号 144-80-9

Sulfacetamide (NSC-63871) 是一种抗生素，通过限制细菌生存所需的叶酸的存在来治疗睑缘炎或结膜炎，有潜力用于眼部感染的研究。

规格	价格	库存
500 mg	¥ 163	现货
1 g	¥ 247	现货
5 g	¥ 572	现货
10 g	¥ 837	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

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产品介绍

Sulfacetamide AI Summary

Sulfacetamide demonstrates significant antibacterial, antiviral, and antifungal properties. It shows antimicrobial activity against a variety of bacterial strains including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii, with MIC values ranging from 1.0 to 2000.0 ug/mL and inhibition zones up to 28.0 mm. Antiviral activity includes inhibition of SARS-CoV-2-induced cytotoxicity in various cell lines with a hit score of 0.2126 and an IC50 value greater than 19952.62 nM. It also inhibits SARS-CoV-2 3CL-Pro protease by 13.66% at 20 µM. Sulfacetamide shows antifungal activity against Candida albicans and Cryptococcus neoformans with respective inhibition rates of 1.53% and 0.24%. It has a pKa value ranging from 5.25 to 5.78, indicating it is a weak acid, and a partition coefficient (log P) of -0.96. Additionally, it displays selective inhibition of human and bovine DHFR and antimicrobial effects against Mycobacterium tuberculosis. Its broad bioactivity spectrum includes inhibition of human HDAC6 (-15.32% and -2.04%) and several receptors with AC50 values over 10,000.0 nM. Sulfacetamide has high water solubility (6470.0 ug/mL) and modest bioactivity related to drug-induced liver injury and binding affinity to proteins. The overall data suggest Sulfacetamide is a versatile molecule with potential therapeutic applications across various infectious and non-infectious diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfacetamide (NSC-63871) is used to treat blepharitis or conjunctivitis (in eye-drop solution) by limiting the presence of folic acid which bacteria need to survive. sulfacetamide may serve as a treatment for mild forms of hidradenitis suppurativa. It is also used to control acne.
别名	磺胺醋酰, Sulphacetamide, Sebizon, Region, NSC-63871, NSC63871, NSC 63871, Acetosulfamine

化学信息

分子量	214.24
分子式	C₈H₁₀N₂O₃S
CAS No.	144-80-9
Smiles	CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1
密度	1.3844 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: Insoluble

DMSO: 55 mg/mL (256.72 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.34 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6677 mL	23.3383 mL	46.6766 mL	233.3831 mL
5 mM	0.9335 mL	4.6677 mL	9.3353 mL	46.6766 mL
10 mM	0.4668 mL	2.3338 mL	4.6677 mL	23.3383 mL
20 mM	0.2334 mL	1.1669 mL	2.3338 mL	11.6692 mL
50 mM	0.0934 mL	0.4668 mL	0.9335 mL	4.6677 mL
100 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3338 mL