o-Phenanthroline

Name: o-Phenanthroline
Brand: TargetMol
SKU: T5983
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.85%

货号 T5983Cas号 66-71-7

别名 1,10-菲罗啉, 1,10-Phenanthroline

o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂，能够与 Fe2+形成红色螯合物，在 510 nm 处最大吸收，可防止链脲佐菌素诱导染色体畸变。它也是一种MMP 的抑制剂。

o-Phenanthroline

一键复制产品信息

很棒

纯度: 98.85%

货号 T5983 别名 1,10-菲罗啉, 1,10-PhenanthrolineCas号 66-71-7

规格	价格	库存
25 mg	¥ 198	现货
50 mg	¥ 289	现货
100 mg	¥ 413	现货
500 mg	¥ 619	现货
1 g	¥ 790	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

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纯度: 98.85%

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COA LCMS HNMR 产品操作手册

产品介绍

o-Phenanthroline AI Summary

o-Phenanthroline exhibits a wide spectrum of bioactivities, including inhibitory effects on human farnesyltransferase with an IC50 of 4,000,000 nM, indicating its potential role in interfering with the farnesylation process. It demonstrates cytotoxic activity against both cisplatin-sensitive and -resistant A2780 ovarian cancer cell lines, with IC50 values of 3660.0 nM and 2730.0 nM, respectively. The compound inhibits N8-Acetylspermidine deacetylase from rat liver cytosol (Ki = 1,300,000 nM) and shows antibacterial activity against E. coli, P. aeruginosa, and S. aureus (MIC = 32.0 µg/mL). Additionally, o-Phenanthroline inhibits Chryseobacterium indologenes metallo-beta-lactamase (Ki = 7300.0 nM) and Pseudomonas aeruginosa VIM-1 and VIM-13 beta-lactamases with IC50 values of 73000.0 nM and 69300.0 nM, respectively. The compound demonstrates antimycobacterial activity against Mycobacterium smegmatis and varied inhibition of fungal, viral, and bacterial enzymes, including anthrax lethal factor and multiple matrix metalloproteinases. It inhibits acrAB AcrAB-TolC-mediated Nile Red efflux in E. coli and shows allosteric modulation at CCR8, CCR5, and CCR1 receptors. Moreover, o-Phenanthroline inhibits beta-lactamases in various bacterial strains, including NDM1, VIM2, and IMP1, and shows chelating activity that inhibits Clostridium botulinum enzyme activity (>95%). It also exhibits anti-tachyzoite activity against Toxoplasma gondii, with ED50 values of 2.01 µM and 2.28 µM after 72 and 96 hours, respectively, and a CC50 value of 70200.0 nM against NHDF cells, resulting in a selectivity index of 31.0. o-Phenanthroline possesses inhibitory potential against a variety of biological targets, making it a promising candidate for further pharmacological exploration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.
别名	1,10-菲罗啉, 1,10-Phenanthroline

化学信息

分子量	180.21
分子式	C₁₂H₈N₂
CAS No.	66-71-7
Smiles	c1cnc2c(c1)ccc1cccnc21
密度	1.25 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度信息

DMSO: 250 mg/mL (1387.27 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (11.1 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5491 mL	27.7454 mL	55.4908 mL	277.4541 mL
5 mM	1.1098 mL	5.5491 mL	11.0982 mL	55.4908 mL
10 mM	0.5549 mL	2.7745 mL	5.5491 mL	27.7454 mL
20 mM	0.2775 mL	1.3873 mL	2.7745 mL	13.8727 mL
50 mM	0.1110 mL	0.5549 mL	1.1098 mL	5.5491 mL
100 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7745 mL