核受体 (Nuclear Receptors)

PPAR alpha PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869.

Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).

Expression system: E. coli
Length: 1-505, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-598, Full Length
Activity: Not Tested

Vitamin D Receptor VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.

Expression system: P. pastoris (Yeast)
Length: 1-477, Full Length of Isoform 1
Activity: Not Tested

Expression system: E. coli
Length: 171-441, Partial
Activity: Not Tested

Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone ligand-binding domain, THRB isoform 1 2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1 eIF4G pathway.

Expression system: E. coli
Length: 551-919, Partial
Activity: Not Tested

Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Expression system: E. coli
Length: 1-434, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-468, Full Length of Isoform 4
Activity: Not Tested

Expression system: E. coli
Length: 1-518, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-402, Full Length of Isoform 3
Activity: Not Tested

Expression system: E. coli
Length: 1-490, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-404, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-598, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-323 of Isoform 3, Partial of Isoform 3
Activity: Not Tested

Expression system: E. coli
Length: 212-460, Partial
Activity: Not Tested

Vitamin D Receptor VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.

Expression system: P. pastoris (Yeast)
Length: 2-530, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-404, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-461, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-477, Full Length
Activity: Not Tested