Naproxen

Name: Naproxen
Brand: TargetMol
SKU: T1582
Price: 310 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T1582Cas号 22204-53-1

别名 萘普生, (S)-Naproxen

Naproxen ((S)-Naproxen) 是COX-1和COX-2的抑制剂，在细胞试验中IC50值分别为8.72 和5.15 μM。它是丙酸衍生物和非甾体抗炎药，具有抗炎、解热和镇痛活性。

Naproxen

一键复制产品信息

很棒

纯度: 99.89%

货号 T1582 别名 萘普生, (S)-NaproxenCas号 22204-53-1

Naproxen ((S)-Naproxen) 是COX-1和COX-2的抑制剂，在细胞试验中IC50值分别为8.72 和5.15 μM。它是丙酸衍生物和非甾体抗炎药，具有抗炎、解热和镇痛活性。

规格	价格	库存
500 mg	¥ 310	现货
1 g	¥ 353	现货
2 g	¥ 397	现货
5 g	¥ 471	现货
10 g	¥ 755	现货
1 mL x 10 mM (in DMSO)	¥ 375	现货

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产品介绍

Naproxen AI Summary

Naproxen exhibits a comprehensive range of bioactivities and physicochemical properties relevant to pharmacological research. It demonstrates significant binding affinity to human serum albumin with a binding constant of Log K' = 0.25, indicating specific interaction potential. The compound shows effective permeability in humans with a Peff value of 8.3, a pKa value of 4.01, and a log P of 3.58, which suggests favorable absorption characteristics. Its bioactivity profile includes inhibition of prostaglandin synthetase in mouse brain microsomes (IC50 of 13,000 nM), superior anti-inflammatory properties (COX-1 IC50 at 2,700 nM, and COX-2 IC50 at 9,700 nM), and analgesic effects in several inflammation models such as adjuvant-induced arthritis with an ED50 of 0.94 mg/kg. Naproxen also exhibits interactions with cellular targets like the Thyroid Stimulating Hormone Receptor and Mitochondrial Division, indicating broad bioactivity. It displays anti-inflammatory activity with an 81.81% inhibition of carrageenan-induced paw edema in rats at 30 mg/kg and low ulcerogenic activity with a UI of 2.25 at 90 mg/kg. The compound has been observed to interact with lipid peroxidation processes and shows a favorable therapeutic index. Furthermore, Naproxen selectively inhibits COX enzymes, with a higher potency for COX-1 (IC50 at 11,000 nM) over COX-2 (IC50 at 1,010,000 nM), suggesting specific anti-inflammatory action. It also exhibits anti-nociceptive effects and potential hepatotoxicity based on enzyme activity and liver function tests. Its binding affinity to amyloid beta fibrils (Ki of 5.7 nM) suggests possible applications in neurodegenerative disease research. Pharmacokinetically, it shows high bioavailability with extensive binding to plasma proteins (log K of 3.34 in octanol-water partitioning). The compound displays efficient inhibition of various enzymatic pathways (notably aIC50 of 480 nM for AKR1C3) and low permeability across certain membrane models. Overall, Naproxen presents a multi-faceted bioactivity profile with potential therapeutic implications across inflammation, pain relief, and possibly neurodegeneration, meriting further detailed pharmacological and toxicological investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
靶点活性	COX-2:5.15 μM, COX-1:8.72 μM
别名	萘普生, (S)-Naproxen

化学信息

分子量	230.26
分子式	C₁₄H₁₄O₃
CAS No.	22204-53-1
Smiles	[C@H](C(O)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
密度	1.1450 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (195.43 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.69 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3429 mL	21.7146 mL	43.4292 mL	217.1458 mL
5 mM	0.8686 mL	4.3429 mL	8.6858 mL	43.4292 mL
10 mM	0.4343 mL	2.1715 mL	4.3429 mL	21.7146 mL
20 mM	0.2171 mL	1.0857 mL	2.1715 mL	10.8573 mL
50 mM	0.0869 mL	0.4343 mL	0.8686 mL	4.3429 mL
100 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1715 mL