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4-Methyldaphnetin

Name: 4-Methyldaphnetin
Brand: TargetMol
SKU: TJS0315
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.73%

货号 TJS0315Cas号 2107-77-9

别名 DHMC, 7,8-二羟基-4-甲基香豆素, 7,8-Dihydroxy-4-methylcoumarin, 4-甲基瑞香素

4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。

4-Methyldaphnetin

一键复制产品信息

很棒

纯度: 99.73%

货号 TJS0315 别名 DHMC, 7,8-二羟基-4-甲基香豆素, 7,8-Dihydroxy-4-methylcoumarin, 4-甲基瑞香素Cas号 2107-77-9

规格	价格	库存	数量
50 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.73%

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COA HNMR LCMS 产品操作手册

产品介绍

4-Methyldaphnetin AI Summary

4-Methyldaphnetin exhibits a diverse range of bioactivities across several assays. It shows moderate inhibition of AFB1 binding to DNA in rat liver microsomes, with inhibition percentages ranging from 8.2% to 8.9% and displays a weak activation effect on the transacetylase catalyzed activation of NADPH cytochrome C reductase (2.5% to 3.5%). Notably, 4-Methyldaphnetin induces apoptosis in human U937 cells with an activity level of 55.0% at 250 µM after 24 hours and manifests cytotoxicity with a CC50 of 165,400.0 nM after 48 hours, along with growth inhibition (IC50 of 48,650.0 nM). It also inhibits alpha-glucosidase activity with IC50 values around 52,700.0 nM. The compound further demonstrates antioxidant activity, as shown by the FRAP test and DPPH radical scavenging activity, with various IC50 values indicating its capacity to neutralize free radicals. 4-Methyldaphnetin has significant inhibitory effects on OATP1B1 and OATP1B3 transporters, with inhibition rates of 61.23% and 78.2%, respectively. It displays antiviral activity, notably against Influenza A virus with an IC50 of 91.5 µg/mL and shows inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 greater than 20,000 nM. Additionally, the compound inhibits Mcl-1 protein, having a Ki value of 2110.0 nM and an IC50 value of 11,210.0 nM. Moreover, 4-Methyldaphnetin demonstrates inhibitory effects on several enzymatic and cellular targets, including rat lens aldose reductase (IC50 of 10,000.0 nM), alpha-glucosidase (IC50 values approximately 52,000.0 nM), as well as several other proteins and pathways such as Lamin A splicing, Human Jumonji Domain Containing 2E, Tau fibril formation, and ERK signaling pathway. It also acts as a modulator of vitamin D receptor, ROR gamma transcriptional activity, and has cytotoxic effects on cancer cells with p53 mutations. These multifaceted bioactivities suggest that 4-Methyldaphnetin holds potential therapeutic implications across a spectrum of diseases, including oxidative stress-related conditions, viral infections, enzymatic dysregulations, and various forms of cancer..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.

别名

DHMC, 7,8-二羟基-4-甲基香豆素, 7,8-Dihydroxy-4-methylcoumarin, 4-甲基瑞香素

化学信息

分子量	192.17
分子式	C₁₀H₈O₄
CAS No.	2107-77-9
Smiles	Cc1cc(=O)oc2c(O)c(O)ccc12
密度	1.456g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 35 mg/mL (182.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.41 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2037 mL	26.0186 mL	52.0373 mL	260.1863 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL	52.0373 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL	26.0186 mL
20 mM	0.2602 mL	1.3009 mL	2.6019 mL	13.0093 mL
50 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL
100 mM	0.0520 mL	0.2602 mL	0.5204 mL	2.6019 mL