Name: ZM323881
Brand: TargetMol
SKU: T21540
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

1-2周

50 mg

¥ 13,800

1-2周

100 mg

¥ 17,500

1-2周

生物活性

产品描述	ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.
靶点活性	VEGFR2:2 nM
体外活性	ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity and demonstrates excellent selectivity compared with other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC 50 >50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC 50 =8 nM) and VEGFR2 tyrosine phosphorylation [1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM [2].

化学信息

分子量	375.4
分子式	C₂₂H₁₈FN₃O₂
CAS No.	193001-14-8
Smiles	N(C=1C2=C(C=C(OCC3=CC=CC=C3)C=C2)N=CN1)C4=C(F)C=C(C)C(O)=C4
密度	1.342 g/cm3 (Predicted)