购物车

您的购物车当前为空

Funapide

Name: Funapide
Brand: TargetMol
SKU: T15358
Price: 1490 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.91%

货号 T15358Cas号 1259933-16-8

别名 XEN402, TV 45070

Funapide (TV 45070) 是一个有效的钠通 Nav1.7 抑制剂，据有潜在的抗炎活性，可用来治疗红斑性肢痛症、肌肉骨骼疼痛、膝关节炎以及疱疹后神经。

为众多的药物研发团队赋能，

让新药发现更简单！

Funapide

一键复制产品信息

很棒

纯度: 99.91%

货号 T15358 别名 XEN402, TV 45070Cas号 1259933-16-8

Funapide (TV 45070) 是一个有效的钠通 Nav1.7 抑制剂，据有潜在的抗炎活性，可用来治疗红斑性肢痛症、肌肉骨骼疼痛、膝关节炎以及疱疹后神经。

规格	价格	库存
1 mg	¥ 1,490	现货
5 mg	¥ 3,270	现货
10 mg	¥ 4,720	现货
25 mg	¥ 7,250	现货
50 mg	¥ 9,780	现货
100 mg	¥ 12,900	现货
200 mg	¥ 17,700	现货
1 mL x 10 mM (in DMSO)	¥ 2,970	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.91%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Funapide AI Summary

Funapide has been shown to exhibit significant bioactivity targeting voltage-gated sodium channels, particularly Nav1.7, in various assays. It displayed an IC50 value of 3.0 nM in a guanidine influx assay, indicating its potency in modulating these channels. The compound demonstrates high selectivity and inhibitory potency against human Nav1.7 with an IC50 of 3.0 nM and a binding affinity (Kd) to the inactivated state of Nav1.7 at 161.0 nM. It also inhibits other sodium channel subtypes such as Nav1.5 (IC50 = 84.0 nM), Nav1.6 (IC50 = 173.0 nM), and Nav1.2 (IC50 = 601.0 nM). In vivo, Funapide shows analgesic efficacy in a rat model of chronic inflammatory pain and reduces histamine-induced pruritis in ICR mice. Clinical trials in humans reveal moderate plasma concentrations when administered topically, reaching a Cmax of 2.315 nM. These findings suggest Funapide's potential as a therapeutic agent primarily targeting Nav1.7 for pain management..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves.
别名	XEN402, TV 45070

化学信息

分子量	429.35
分子式	C₂₂H₁₄F₃NO₅
CAS No.	1259933-16-8
Smiles	FC(F)(F)c1ccc(CN2C(=O)[C@@]3(COc4cc5OCOc5cc34)c3ccccc23)o1
密度	1.59 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 85.87 mg/mL (200 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3291 mL	11.6455 mL	23.2910 mL	116.4551 mL
5 mM	0.4658 mL	2.3291 mL	4.6582 mL	23.2910 mL
10 mM	0.2329 mL	1.1646 mL	2.3291 mL	11.6455 mL
20 mM	0.1165 mL	0.5823 mL	1.1646 mL	5.8228 mL
50 mM	0.0466 mL	0.2329 mL	0.4658 mL	2.3291 mL
100 mM	0.0233 mL	0.1165 mL	0.2329 mL	1.1646 mL