Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR/HER2-IN-8 (compound 34) 是EGFR/HER2和DHFR 的抑制剂,其对 EGFR,HER2 和 DHFR 的IC50值分别为 0.45,0.244 和 5.669 μM。EGFR/HER2-IN-8 可用于癌症研究,它对多种癌细胞系表现出抗癌活性,具有高安全性和选择性指数。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | EGFR/HER2-IN-8 (compound 34) is an inhibitor of EGFR/HER2 and DHFR with IC50 values of 0.45, 0.244 and 5.669 μM for EGFR, HER2 and DHFR, respectively. EGFR/HER2-IN-8 can be used in the cancer research that exhibits anticancer activity against several cancer cell lines with high safety profile and selectivity indices [1]. |
体外活性 | EGFR/HER2-IN-8 (0-100 μM; 72 h) shows highly potent anticancer activity to HepG2, MCF 7, HCT-116, PC-3 and Hela cell lines and exhibits selective cytotoxicity against cancer cell lines rather than normal cell line [1]. Cell Cytotoxicity Assay [1] Cell Line: HepG2 hepatocellular carcinoma, MCF 7 breast cancer, HCT-116 colorectal carcinoma, PC-3 prostate, Hea cervical epithelioid carcinoma cell lines and WI-38 fetal lung fibroblast cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Exibited more potent cytotoxicity than SOR towards HepG2, MCF 7, HCT-116, PC-3 and Hela cell lines with IC 50 s of 7.34, 5.19, 9.23, 18.5 and 13.02 μM, respectively. Showed weak cytotoxic activity against WI-38 cell line with an IC 50 value of 67.25 μM, and possessed best selectivity indices towards MCF-7 breast cancer cell line. |
分子量 | 328.39 |
分子式 | C16H16N4O2S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
EGFR/HER2-IN-8 Inhibitor inhibitor inhibit