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SPINK4 Protein, Human, Recombinant (His)

产品编号 TMPY-01454

别名: MGC133107, PEC-60, HEL136, PEC60, serine peptidase inhibitor, Kazal type 4, SPINK4

SPINK4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 8 kDa and the accession number is O60575.

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SPINK4 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	SPINK4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 8 kDa and the accession number is O60575.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	O60575
别名	MGC133107, PEC-60, HEL136, PEC60, serine peptidase inhibitor, Kazal type 4, SPINK4
蛋白构建	The Human SPINK4 (NP_055286.1) (Met 1-Cys 86) was expressed, fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged infertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.

参考文献

1. Schneider, A. et al., 2004,Gastroenterol Clin North Am. 33 (4): 789-806. 2. Wapenaar, MC. et al., 2007, Immunogenetics. 59 (5): 349-57. 3. Brattsand, M. et al., 2009, J Invest Dermatol. 129 (7): 1656-65. 4. Chen, T. et al., 2009, Proteins. 77 (1): 209-19. 5. Noah, TK. et al., 2010, Exp Cell Res. 316 (3): 452-65.

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Keywords

SPINK4 Protein, Human, Recombinant (His) SPINK-4 MGC-133107 MGC133107 PEC 60 PEC-60 HEL136 SPINK 4 HEL-136 PEC60 serine peptidase inhibitor, Kazal type 4 HEL 136 MGC 133107 SPINK4 recombinant recombinant-proteins proteins protein

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