Name: UK-370106
Brand: TargetMol
SKU: T13249
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

¥ 7,850

35日内发货

生物活性

产品描述	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
靶点活性	MMP8:1.75 μM, MMP9:30.4 μM, MMP12:42 nM, MMP7:5.8 μM, MMP2:34.2 μM, MMP13:2.3 μM, MMP14:66.9 μM, MMP3:23 nM
体外活性	UK-370106 potency for the inhibition of MMP-13 is 2.3 μM, some 100-fold less potent than its inhibition of MMP-3. UK-370106 is found to be inactive (IC50 > 100 μM) vs zinc metalloproteases PCP and TACE and possesses the following inhibitory potencies vs MMP-2 (IC50 of 34.2 μM), MMP-7 (IC50 of 5.8 μM), MMP-8 (IC50 of 1.75 μM), MMP-9 (IC50 of 30.4 μM) and MMP-14 (IC50 of 66.9 μM)[1]. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM)[1].
体内活性	Following iv (rat; 2 mg/kg) or topical administration to dermal wounds (rabbit), UK-370106 (compound 7) is cleared rapidly (t1/2 = 23 min) from plasma, but slowly (t1/2 approximately 3 days) from dermal tissue. Topical administration of UK-370106 for 6 days substantially inhibits MMP-3 ex vivo in a model of chronic dermal ulcers [1].

化学信息

分子量	572.73
分子式	C₃₅H₄₄N₂O₅
CAS No.	230961-21-4
Smiles	CC1=C(C=CC(CCC[C@@H](C(N[C@H](C(N[C@H](COC)C2=CC=CC=C2)=O)C(C)(C)C)=O)CC(O)=O)=C1)C3=CC=CC=C3
密度	1.123g/cm3