MM41

Name: MM41
Brand: TargetMol
SKU: T60028
Price: 472 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.25%

货号 T60028Cas号 1429028-96-5

MM41 是一种人类端粒和基因启动子 DNA 四链体稳定剂，对 MIA PaCa-2 胰腺癌细胞系的 IC50 <10 nM。

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MM41

一键复制产品信息

很棒

纯度: 99.25%

货号 T60028Cas号 1429028-96-5

MM41 是一种人类端粒和基因启动子 DNA 四链体稳定剂，对 MIA PaCa-2 胰腺癌细胞系的 IC50 <10 nM。

规格	价格	库存
1 mg	¥ 472	现货
5 mg	¥ 1,190	现货
10 mg	¥ 1,890	现货
25 mg	¥ 3,090	现货
50 mg	¥ 4,150	现货
100 mg	¥ 5,710	现货
200 mg	¥ 7,680	现货
1 mL x 10 mM (in DMSO)	¥ 1,630	现货

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COA HNMR LCMS 产品操作手册

产品介绍

MM41 AI Summary

MM41 induces senescence in human MIAPaCa2 cells and modulates gene expression by downregulating SLX4, RASSF1, and PTEGES3, while upregulating PRKCB, PPARG, NHP2, and MYC genes. It exhibits cytotoxicity against various human cell lines such as PANC1, MIAPaCa2, MCF7, and A549, with varying IC50 values from 3.0 nM to 230.0 nM. Specifically, it has an IC50 value of 3.0 nM after 96 hours in human PANC1 cells, as determined by the SRB assay. In vivo studies show that the compound demonstrates antitumor activity against MIAPaCa2 xenografts in CD-1 nude mice, achieving significant reductions in tumor volume when administered at 15 mg/kg intravenously twice weekly for 4 weeks, though toxicity emerges at a maximum tolerated dose of 25.0 mg/kg. Additionally, MM41 selectively binds to various G-quadruplex RNA and DNA structures, including the human telomeric G-quadruplex and TERT hairpin duplex DNA, exhibiting binding affinities with dissociation equilibrium constants ranging from 2.0 nM to 10.0 nM. It stabilizes the promoter sequences of HSP90a and HSP90b, as well as the human telomeric G-quadruplex, indicated by significant changes in melting temperatures. These stabilizing effects vary, causing melting temperature increases from 4.9°C to 33.1°C for different DNA structures, and a reduced melting temperature change of less than 2.0°C for TERT hairpin duplex DNA. Such properties suggest its broad potential in cancer therapy, providing differential cytotoxic and binding activities that could be leveraged against diverse cell lines and DNA structures..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.

化学信息

分子量	831.06
分子式	C₄₄H₆₆N₁₀O₆
CAS No.	1429028-96-5
Smiles	CN1CCN(CCCNc2cc3c4c(c(NCCCN5CCN(C)CC5)cc5c4c2c(=O)n(CCCN2CCOCC2)c5=O)c(=O)n(CCCN2CCOCC2)c3=O)CC1
颜色	Blue
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (36.1 mM), when pH is adjusted to 8 with HCl. Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2033 mL	6.0164 mL	12.0328 mL	60.1641 mL
5 mM	0.2407 mL	1.2033 mL	2.4066 mL	12.0328 mL
10 mM	0.1203 mL	0.6016 mL	1.2033 mL	6.0164 mL
20 mM	0.0602 mL	0.3008 mL	0.6016 mL	3.0082 mL