规格

价格

库存

数量

1 mg

¥ 282

现货

2 mg

¥ 398

现货

5 mg

¥ 728

现货

10 mg

¥ 1,180

现货

25 mg

¥ 2,420

现货

50 mg

¥ 3,590

现货

100 mg

¥ 5,190

现货

500 mg

¥ 10,900

现货

1 mL x 10 mM (in DMSO)

¥ 732

现货

生物活性

产品描述	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
体外活性	TUG-891与LCFA α-亚麻酸在人体FFA4上显示出相似的信号特性，包括促进Ca2+动员、β-阿雷斯汀-1和β-阿雷斯汀-2的招募以及细胞外信号调节激酶的磷酸化。TUG-891激活人体FFA4还导致受体的快速磷酸化和内化[1]。
激酶实验	Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].
别名	TUG891, TUG 891

化学信息

分子量	364.41
分子式	C₂₃H₂₁FO₃
CAS No.	1374516-07-0
Smiles	C(OC1=CC=C(CCC(O)=O)C=C1)C2=C(C=CC(F)=C2)C3=CC=C(C)C=C3
密度	1.199 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 40 mg/mL (109.77 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.49 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO