Name: Trevogrumab
Brand: TargetMol
SKU: T80951
Price: 2650 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,650

现货

5 mg

¥ 6,150

现货

10 mg

¥ 8,280

现货

25 mg

¥ 12,300

现货

50 mg

¥ 16,500

现货

生物活性

产品描述	Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.
体外活性	Trevogrumab （40nM，30分钟）处理人类骨骼成肌细胞，WesternBlot检测目标蛋白的水平变化。结果：Trevogrumab 有效抑制肌肉生长抑制素诱导的Smad2/3激活，表现出高亲和力和特异性。[1]
体内活性	Trevogrumab (0.1-30 mg/kg，皮下注射，每周两次，持续 4 周处理小鼠，结果小鼠腓肠肌（GA）和胫骨前肌（TA）肌肉重量显着增加（~20%），小鼠肌纤维面积增加（~15%）。[1]
别名	曲戈卢单抗, REGN-1033, REGN1033
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG4 kappa
推荐同型对照	Human IgG4 (S228P) kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	144.02 kDa
CAS No.	1429201-24-0

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Trevogrumab