ELQ-300

Name: ELQ-300
Brand: TargetMol
SKU: T5477
Price: 273 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.28%

货号 T5477Cas号 1354745-52-0

ELQ-300 是一种有口服生物活性的抗疟疾剂，可作为细胞色素 bc1 复合物的还原位点的抑制剂

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ELQ-300

一键复制产品信息

很棒

纯度: 97.28%

货号 T5477Cas号 1354745-52-0

ELQ-300 是一种有口服生物活性的抗疟疾剂，可作为细胞色素 bc1 复合物的还原位点的抑制剂

规格	价格	库存
1 mg	¥ 273	现货
5 mg	¥ 596	现货
10 mg	¥ 953	现货
25 mg	¥ 1,930	现货
50 mg	¥ 2,770	现货
100 mg	¥ 3,880	现货
200 mg	¥ 5,280	现货
1 mL x 10 mM (in DMSO)	¥ 592	现货

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COA HNMR LCMS 产品操作手册

产品介绍

ELQ-300 AI Summary

ELQ-300 exhibits potent antimalarial activity, demonstrating high solubility at pH 6.8 with solubility levels below 1000.0 nM. It is notably effective against clinical isolates of Plasmodium falciparum with an EC50 value of 1.0 nM and shows low EC50 values across various strains of Plasmodium falciparum and Plasmodium yoelii. The compound specifically targets the malaria parasite's cytochrome bc1 complex with high selectivity and minimal cytotoxicity against human HepG2 cells. It showcases remarkable effectiveness against blood-stage infections of Plasmodium yoelii in mice with ED50 values as low as 0.016 mg kg-1 and demonstrates a low IC50 of 5.0 nM against Plasmodium falciparum 3D7 and 3.0 nM against atovaquone-resistant strains. Additionally, ELQ-300 exhibits significant antimalarial activity in vivo against various Plasmodium falciparum strains and has an IC50 of 20.0 nM against wild-type Dd2 and 148.0 nM against drug-resistant Dd2 harboring the CytB Ile22Leu mutation, highlighting its potential as a promising candidate for antimalarial drug development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1)

化学信息

分子量	475.84
分子式	C₂₄H₁₇ClF₃NO₄
CAS No.	1354745-52-0
Smiles	COc1cc2[nH]c(C)c(-c3ccc(Oc4ccc(OC(F)(F)F)cc4)cc3)c(=O)c2cc1Cl
密度	1.362 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 15.62 mg/mL (32.83 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1015 mL	10.5077 mL	21.0155 mL	105.0773 mL
5 mM	0.4203 mL	2.1015 mL	4.2031 mL	21.0155 mL
10 mM	0.2102 mL	1.0508 mL	2.1015 mL	10.5077 mL
20 mM	0.1051 mL	0.5254 mL	1.0508 mL	5.2539 mL