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Dimetridazole

Name: Dimetridazole
Brand: TargetMol
SKU: T0874
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 T0874Cas号 551-92-8

别名 二甲硝咪唑, 1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazole

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) 是一种对抗原生动物感染的硝基咪唑类药物。

Dimetridazole

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很棒

纯度: 99.88%

货号 T0874 别名 二甲硝咪唑, 1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazoleCas号 551-92-8

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) 是一种对抗原生动物感染的硝基咪唑类药物。

规格	价格	库存
200 mg	¥ 113	现货
500 mg	¥ 163	现货
1 g	¥ 247	待询
5 g	¥ 572	现货
10 g	¥ 837	待询
1 mL x 10 mM (in DMSO)	¥ 163	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.88%

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资源下载:

COA HNMR LCMS HPLC 产品操作手册

产品介绍

Dimetridazole AI Summary

Dimetridazole demonstrates a broad spectrum of biological activities. It exhibits in vitro anti-trichomonal activity against Trichomonas foetus-Ortho strain-2 with an ED50 of 0.3 µg/ml and against Trichomonas vaginalis TVR87 with an IC50 of 708.0 nM. The compound shows mutagenic effects in Trichomonas foetus at 15.0% relative to Ronidazole and against Salmonella Typhimurium YG1042 and TA100. In terms of selectivity, it has a high specificity index of >2501.0, indicating greater selectivity toward Trichomonas vaginalis over human THP1 cells. For anticarcinogenic activity, Dimetridazole has a TD50 value of 120.46 µmol/Kg in rat models and a pTD50 value of 2.081, reflecting its potency in tumor inhibition. It also demonstrates the potential to inhibit the entry of the Ebola virus across various channels with AC50 values ranging from 562.3 nM to 44.67 µM. In combating SARS-CoV-2, the compound shows mixed antiviral results. It has a low inhibition index of 0.5596 in Vero E6 cells and a minor inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration, with percentages of -2.64% and 0.02% respectively. Moreover, it inhibits the SARS-CoV-2 3CL-Pro protease by 7.611% at 20 µM. Finally, the compound's enzymatic activity against human HDAC6 shows varied inhibition: 7.7% with a commercial peptide substrate and -7.43% with a custom peptide substrate. Dimetridazole has a safety index of 8.9, suggesting a relative margin between effective and toxic doses across its various biological activities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.
别名	二甲硝咪唑, 1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazole

化学信息

分子量	141.13
分子式	C₅H₇N₃O₂
CAS No.	551-92-8
Smiles	N(=O)(=O)C=1N(C)C(C)=NC1
密度	1.36 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (177.14 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.17 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.0857 mL	35.4283 mL	70.8567 mL	354.2833 mL
5 mM	1.4171 mL	7.0857 mL	14.1713 mL	70.8567 mL
10 mM	0.7086 mL	3.5428 mL	7.0857 mL	35.4283 mL
20 mM	0.3543 mL	1.7714 mL	3.5428 mL	17.7142 mL
50 mM	0.1417 mL	0.7086 mL	1.4171 mL	7.0857 mL
100 mM	0.0709 mL	0.3543 mL	0.7086 mL	3.5428 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Parasite Inhibitor inhibit Dimetridazole Antibiotic

Dimetridazole

Dimetridazole

Dimetridazole 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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