Name: RMC-6272
Brand: TargetMol
SKU: T39959
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 25,700

6-8周

生物活性

产品描述	RMC-6272 (RM-006) is a bi-steric inhibitor that selectively targets mTORC1, displaying potent and selective (> 10-fold) inhibition over mTORC2. Compared to Rapamycin, RMC-6272 demonstrates enhanced inhibition of mTORC1 and induces increased cell death in TSC2 null tumors.
体外活性	RMC-6272 shows more effective growth inhibition in multiple TSC1 or TSC2 mutant tumor cell lines compared to Rapamycin. RMC-6272 causes a more profound growth inhibition in the TSC1 or TSC2 mutant cells than the wild type cells. RMC-6272 at ~1 nM shows near complete inhibition of p4E-BP1 T37/46 , while inhibition of pS6 S240/244 levels is similar for Rapamycin and RM compounds[1].
体内活性	RMC-6272 markedly reduces kidney tumor burden in Tsc2 +/- A/J mice after four weeks of treatment. Tumor regrowth is assessed two months after treatment cessation, tumor burden is significantly reduced in the RMC-6272 group as compared to the Rapamycin and MLN0128 groups[1].
别名	RMC-6272, RM-006

化学信息

分子量	1850.25
分子式	C₉₅H₁₄₁FN₆O₂₇S
CAS No.	2382769-46-0
Smiles	[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(C[C@@H](O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCS(=O)(=O)c2ccc(C(=O)N3CCOc4ccc(cc4C3)-c3ccc(N)nc3)c(C)c2F)[C@@H](C1)OC
密度	1.28 g/cm3 (Predicted)