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EGCG Octaacetate

Name: EGCG Octaacetate
Brand: TargetMol
SKU: T8160
Price: 208 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 乙酰化表没食子儿茶素没食子酸酯, 乙酰化EGCG

货号 T8160Cas号 148707-39-5 一键复制产品信息纯度: 99.25%

很棒

EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药，对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平，减少小鼠结肠炎引起的结肠癌。

EGCG Octaacetate

一键复制产品信息

很棒

纯度: 99.25%

货号 T8160Cas号 148707-39-5

别名 乙酰化表没食子儿茶素没食子酸酯, 乙酰化EGCG

规格	价格	库存
1 mg	¥ 208	现货
5 mg	¥ 460	现货
10 mg	¥ 665	现货
25 mg	¥ 1,080	现货
50 mg	¥ 1,620	现货
1 mL x 10 mM (in DMSO)	¥ 780	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.53%

颜色: 白色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

EGCG Octaacetate AI Summary

EGCG Octaacetate demonstrates multifaceted bioactivities, including inhibition of the chymotrypsin-like activity of the 20S proteasome at 50 µM with an inhibition rate of less than 20%. It exhibits antiviral properties against Influenza A/PR8/34(H1N1) in dog MDCK cells with an EC50 of 77000 nM and against Influenza A/PR8/34(H1N1) with an EC50 of 8490 nM. The compound also shows antiproliferative effects against human MDA-MB-231 cells, with no significant growth inhibition at 25 to 50 µM after 24 hours unless the cells have high catechol-O-methyltransferase (COMT) activity, where it achieves a 42% inhibition at 25 µM. Notably, the antiproliferative effect is enhanced to 89% in the presence of a COMT inhibitor, 3,5-dinitrocatechol, at the same concentration. Furthermore, EGCG Octaacetate induces AMPKalpha phosphorylation in human MDA-MB-231 cells at 20 µM after 3 hours, showing a fold change of 3.9 relative to control, which is associated with regulation of energy metabolism, cell growth, and autophagy. The compound exhibits minimal inhibition (0.5%) of rat liver microsomal Steroid 5-alpha-reductase at 5 µM after 30 minutes. Additionally, it demonstrates cytotoxicity against human LCC-6 cells, human MDA435/LCC6MDR cells, and mouse L929 cells with modulation of P-glycoprotein (P-gp) in human MDA435/LCC6MDR cells leading to the reversal of paclitaxel resistance. This is evidenced by the reduction of paclitaxel IC50 from 152.5 ± 9.7 µM to 176.1 nM after 5 days, indicating significant improvement in paclitaxel sensitivity in these resistant cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.
别名	乙酰化表没食子儿茶素没食子酸酯, 乙酰化EGCG

化学信息

分子量	794.67
分子式	C₃₈H₃₄O₁₉
CAS No.	148707-39-5
Smiles	CC(=O)Oc1cc(OC(C)=O)c2C[C@@H](OC(=O)c3cc(OC(C)=O)c(OC(C)=O)c(OC(C)=O)c3)[C@H](Oc2c1)c1cc(OC(C)=O)c(OC(C)=O)c(OC(C)=O)c1
密度	1.46 g/cm3 (Predicted)

储存&溶解度

存储

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 125 mg/mL (157.3 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (2.52 mM), Sonication is recommended.

10% DMSO+90% Saline: < 10 mg/mL (12.58 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (12.58 mM), Solution.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2584 mL	6.2919 mL	12.5838 mL	62.9192 mL
5 mM	0.2517 mL	1.2584 mL	2.5168 mL	12.5838 mL
10 mM	0.1258 mL	0.6292 mL	1.2584 mL	6.2919 mL
20 mM	0.0629 mL	0.3146 mL	0.6292 mL	3.1460 mL
50 mM	0.0252 mL	0.1258 mL	0.2517 mL	1.2584 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.6292 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

prodrug PI3K/Akt/NFκB phosphorylation p65 acetylation Inhibitor inhibit gram-positive bacteria gram-negative bacteria EGCG Octaacetate EGCG colitis-driven colon cancer Bacterial AcEGCG

EGCG Octaacetate

EGCG Octaacetate