Casein kinase 1δ-IN-9

Name: Casein kinase 1δ-IN-9
Brand: TargetMol
SKU: T64376
Price: 417 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T64376Cas号 854355-54-7

Casein kinase 1δ-IN-9是一种醌还原酶2(Quinone reductase 2)抑制剂，IC50为0.6μM。

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Casein kinase 1δ-IN-9

一键复制产品信息

很棒

纯度: 99.93%

货号 T64376Cas号 854355-54-7

Casein kinase 1δ-IN-9是一种醌还原酶2(Quinone reductase 2)抑制剂，IC50为0.6μM。

规格	价格	库存
1 mg	¥ 417	现货
5 mg	¥ 993	现货
10 mg	¥ 1,490	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,220	现货
100 mg	¥ 4,130	现货
200 mg	¥ 5,590	现货
1 mL x 10 mM (in DMSO)	¥ 903	现货

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纯度: 99.93%

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产品介绍

Casein kinase 1δ-IN-9 AI Summary

Casein kinase 1δ-IN-9 exhibits a high level of inhibition (99.0%) against Plasmodium falciparum Dd2 and 3D7 in whole red blood cells based on parasite LDH activity at 2 μM concentration. However, it shows no inhibition (0.0%) against Plasmodium falciparum 3D7 LDH activity in an LDH reporter assay at the same concentration and demonstrates no significant cytotoxicity in the human HepG2 cell line assay at 10 μM. The compound has an XC50 value of 664.32 nM in inhibiting Plasmodium falciparum 3D7 in whole erythrocytes. Additionally, it displays varying levels of bioactivity against multiple targets with EC50 values including: Salmonella typhi (>50000.0 nM), Chronic Active B-Cell Receptor Signaling (11220.2 nM), Vitamin D receptor (89125.1 nM), malarial parasite plastid (465.4 nM at 96-hour, 657.3 nM at 48-hour), TGF-b (12589.3 nM), Hepatitis C Virus (2511.9 nM), and others. It also shows 4.77% to 10.95% inhibition against transgenic Leishmania Mexicana promastigotes at 2 μM concentration. The compound's Inhibition Frequency Index (IFI) is 0.0%, indicating insignificant inhibition in non-kinase HTS assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.

化学信息

分子量	269.73
分子式	C₁₅H₁₂ClN₃
CAS No.	854355-54-7
Smiles	N(CC1=CC=CC=N1)C=2C3=C(N=CC2)C=C(Cl)C=C3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (203.91 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7074 mL	18.5371 mL	37.0741 mL	185.3706 mL
5 mM	0.7415 mL	3.7074 mL	7.4148 mL	37.0741 mL
10 mM	0.3707 mL	1.8537 mL	3.7074 mL	18.5371 mL
20 mM	0.1854 mL	0.9269 mL	1.8537 mL	9.2685 mL
50 mM	0.0741 mL	0.3707 mL	0.7415 mL	3.7074 mL
100 mM	0.0371 mL	0.1854 mL	0.3707 mL	1.8537 mL