TD114-2 (compound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 of 48 nM. It forms a hydrogen bond with Arginine 141 (ARG141) in GSK-3β, an amino acid often found as a negatively charged residue in other kinases, contributing to its high selectivity. TD114-2 is applicable for research on diabetes, neurodegenerative diseases, and other conditions related to GSK-3β.