Methiothepin mesylate

Name: Methiothepin mesylate
Brand: TargetMol
SKU: T2190
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T2190Cas号 74611-28-2

别名 马来酸甲硫替平, Ro 8-6837 mesylate, Metitepine mesylate

Methiothepin mesylate (Metitepine mesylate) 是一种有效且非选择性的 5-HT2 受体拮抗剂，用作抗精神病药。

Methiothepin mesylate

一键复制产品信息

很棒

纯度: 99.92%

货号 T2190 别名 马来酸甲硫替平, Ro 8-6837 mesylate, Metitepine mesylateCas号 74611-28-2

Methiothepin mesylate (Metitepine mesylate) 是一种有效且非选择性的 5-HT2 受体拮抗剂，用作抗精神病药。

规格	价格	库存
1 mg	¥ 145	现货
5 mg	¥ 295	现货
10 mg	¥ 492	现货
25 mg	¥ 813	现货
50 mg	¥ 1,190	现货
100 mg	¥ 1,760	现货

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纯度: 99.79%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Methiothepin mesylate AI Summary

Methiothepin mesylate exhibits a broad spectrum of bioactivities spanning antiplasmodial, antiviral, modulatory, and inhibitory properties. It shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 5011.87 nM to 12589.25 nM as determined by the SYBR green assay after 72 hours. This compound is also a differential inhibitor of Plasmodium falciparum proliferation and demonstrates antiviral activities, particularly against SARS-CoV-2, by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease with a 5.834% inhibition at 20µM concentration. Methiothepin mesylate acts as a serotonergic receptor antagonist at 5-HT1A and 5-HT2A receptors, significantly inhibiting serotonin-induced calcium flux with IC50 values of 71.0 nM and 56.0 nM, respectively. It possesses modulatory effects on Lamin A splicing, SMN2 splice variant expression, and multiple signaling pathways, including ERK and TGF-β. The compound exhibits inhibition of other targets like Tyrosyl-DNA Phosphodiesterase (TDP1), Tau fibril formation, JMJD2A-Tudor domain, Nrf2, UBC13 Polyubiquitin interactions, MPP8 Chromodomain interactions, and Human Flap endonuclease 1 (FEN1). It also has implications in the treatment of Gaucher Disease by influencing glucocerebrosidase activity and inducing synthetic lethality in tumor cells. Furthermore, Methiothepin mesylate serves as a tool in high-throughput screenings for inhibitors of RAD52, AMA1-RON, and antimalarial drug development, indicating its broad potential in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.
别名	马来酸甲硫替平, Ro 8-6837 mesylate, Metitepine mesylate

化学信息

分子量	452.65
分子式	C₂₁H₂₈N₂O₃S₃
CAS No.	74611-28-2
Smiles	CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (99.41 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2092 mL	11.0461 mL	22.0921 mL	110.4606 mL
5 mM	0.4418 mL	2.2092 mL	4.4184 mL	22.0921 mL
10 mM	0.2209 mL	1.1046 mL	2.2092 mL	11.0461 mL
20 mM	0.1105 mL	0.5523 mL	1.1046 mL	5.5230 mL
50 mM	0.0442 mL	0.2209 mL	0.4418 mL	2.2092 mL