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3-Hydroxybutyric acid (Butanoic acid) 是人内源性代谢物,一种内源性的组蛋白去乙酰化酶 (HDAC) 抑制剂,对 HDAC3、HDAC4、HDAC1 的 IC50为2.4 mM、4.5 mM、5.3 mM。3-Hydroxybutyric acid有能量代谢、神经保护、抗炎作用、改善胰岛素抵抗作用。

3-Hydroxybutyric acid (Butanoic acid) 是人内源性代谢物,一种内源性的组蛋白去乙酰化酶 (HDAC) 抑制剂,对 HDAC3、HDAC4、HDAC1 的 IC50为2.4 mM、4.5 mM、5.3 mM。3-Hydroxybutyric acid有能量代谢、神经保护、抗炎作用、改善胰岛素抵抗作用。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 10 mg | ¥ 166 | In stock | |
| 25 mg | ¥ 248 | In stock | |
| 50 mg | ¥ 349 | In stock | |
| 100 mg | ¥ 498 | In stock | |
| 500 mg | ¥ 1,190 | In stock |
3-Hydroxybutyric acid 相关产品
| 产品描述 | Butanoic acid is an endogenous human metabolite, an endogenous histone deacetylase (HDAC) inhibitor. The IC50 of HDAC3, HDAC4 and HDAC1 were 2.4 mM, 4.5 mM and 5.3 mM, respectively. 3-Hydroxybutyric acid has the effects of energy metabolism, neuroprotection, anti-inflammatory, and improvement of insulin resistance. |
| 靶点活性 | HDAC1:5.3 mM, HDAC4:4.5 mM, HDAC3:2.4 mM |
| 体外活性 | 方法:HEK293细胞用3-Hydroxybutyric acid(10 mM)处理24小时后,检测组蛋白H3K9在_Foxo3a_和_Mt2_启动子上的乙酰化水平。 |
| 体内活性 | 方法:为研究3-Hydroxybutyric acid的神经保护作用,将3-Hydroxybutyric acid(2 mM或5 mM)通过脑室内注射给予C57BL/6小鼠。 |
| 别名 | Butanoic acid, 3-羟基丁酸 |
| 分子量 | 104.1 |
| 分子式 | C4H8O3 |
| CAS No. | 300-85-6 |
| Smiles | C(C(C)O)C(O)=O |
| 密度 | 1.126 g/cm3 at 25℃ (lit.) |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | store at low temperature,store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | H2O: 200 mg/mL (1921.23 mM), Sonication is recommended. DMSO: 262.5 mg/mL (2521.61 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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H2O/DMSO
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| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 龙芽草/仙鹤草 | Agrimonia pilosa Ldb. | 平 | 苦, 涩 | 心, 肝 |
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