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Pramiracetam

Name: Pramiracetam
Brand: TargetMol
SKU: T0183
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 普拉西坦, CI-879

货号 T0183Cas号 68497-62-1 一键复制产品信息纯度: 99.94%

很棒

Pramiracetam (CI-879) 来源于piracetam，能改善脑外伤引起的认知障碍。它是更有效的促智药物。

Pramiracetam

一键复制产品信息

很棒

纯度: 99.94%

货号 T0183Cas号 68497-62-1

别名 普拉西坦, CI-879

Pramiracetam (CI-879) 来源于piracetam，能改善脑外伤引起的认知障碍。它是更有效的促智药物。

规格	价格	库存
10 mg	¥ 113	现货
25 mg	¥ 173	现货
50 mg	¥ 273	现货
100 mg	¥ 437	现货
200 mg	¥ 642	现货
1 mL x 10 mM (in DMSO)	¥ 191	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.94%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Pramiracetam AI Summary

Pramiracetam demonstrates the ability to reverse electroconvulsive shock-induced amnesia in mice, with the percentage of amnesia reversal ranging from 0.0% at 0.63 mg/kg to 96.0% at 5 mg/kg. However, the effectiveness decreases at a dose of 20.0 mg/kg and significantly drops at 80.0 mg/kg. Additionally, this compound shows bioactivity in inhibiting Plasmodium falciparum (DD2) proliferation with a potency of 7492.9 nM. In terms of antiviral activity, Pramiracetam has demonstrated low to negligible effectiveness against SARS-CoV-2 induced cytotoxicity in various assays and cell models, including Caco-2 and VERO-6 cells, with inhibition percentages ranging from -0.12% to a maximum IC50 value greater than 20000.0 nM. The compound also inhibits the SARS-CoV-2 3CL-Pro protease with varying inhibition percentages. Moreover, it exhibits inhibitory activity on the human HDAC6 enzyme, decreasing enzyme activity by 31.7% with a commercial peptide substrate and by 8.52% with a custom peptide substrate. However, the compound showed no significant bioactivity in assays conducted for various other targets, with all AC50 values being greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the therapy of cognitive disorders of traumatic origins and cerebrovascular.
别名	普拉西坦, CI-879

化学信息

分子量	269.38
分子式	C₁₄H₂₇N₃O₂
CAS No.	68497-62-1
Smiles	C(C(NCCN(C(C)C)C(C)C)=O)N1C(=O)CCC1
密度	1.036 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (185.61 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7122 mL	18.5611 mL	37.1223 mL	185.6114 mL
5 mM	0.7424 mL	3.7122 mL	7.4245 mL	37.1223 mL
10 mM	0.3712 mL	1.8561 mL	3.7122 mL	18.5611 mL
20 mM	0.1856 mL	0.9281 mL	1.8561 mL	9.2806 mL
50 mM	0.0742 mL	0.3712 mL	0.7424 mL	3.7122 mL
100 mM	0.0371 mL	0.1856 mL	0.3712 mL	1.8561 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。