MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7   nM and 1.1-233  nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.

PI3Kα:6.4 nM, PI3Kγ:8.3 nM, PI3Kβ:233 nM, PPARγ:3.4 μM (EC50), PI3Kδ:1.1 nM